{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Callaghan BC"],"funding":["National Institute of Neurological Disorders and Stroke","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","A. Alfred Taubman Medical Research Institute","NINDS NIH HHS","Novo Nordisk Fonden"],"pagination":["2108-2118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8612943"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(12)"],"pubmed_abstract":["<h4>Objective</h4>The aim of this study was to determine the effect of dietary weight loss on neuropathy outcomes in people with severe obesity.<h4>Methods</h4>A prospective cohort study of participants attending a medical weight-management program was followed. Weight loss was achieved with meal replacement of 800 kcal/d for 12 weeks and then transitioning to 1,200 to 1,500 kcal/d. The coprimary outcomes were changes in intraepidermal nerve fiber density (IENFD) at the distal leg and proximal thigh. Secondary outcomes included nerve conduction studies, Michigan Neuropathy Screening Instrument questionnaire and exam, Quality of Life in Neurological Disorders, and quantitative sensory testing.<h4>Results</h4>Among 131 baseline participants, 72 (mean [SD] age: 50.1 [10.5] years, 51.4% female"],"journal":["Obesity (Silver Spring, Md.)"],"pubmed_title":["Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology."],"pmcid":["PMC8612943"],"funding_grant_id":["R24082841","DK094292","P30 DK092926","P30 DK089503","R01 DK115687","NS079417","NNF14°C0011633","T32 NS007222","NS0007222","DK115687","K23 NS079417","R21 NS102924","P30 DK020572","NS102924","NNF14OC0011633","R24 DK082841","DP3 DK094292"],"pubmed_authors":["Chant E","Callaghan BC","Burant CF","Villegas-Umana E","Feldman EL","Reynolds EL","Banerjee M","Akinci G","Rothberg AE"],"additional_accession":[]},"is_claimable":false,"name":"Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology.","description":"<h4>Objective</h4>The aim of this study was to determine the effect of dietary weight loss on neuropathy outcomes in people with severe obesity.<h4>Methods</h4>A prospective cohort study of participants attending a medical weight-management program was followed. Weight loss was achieved with meal replacement of 800 kcal/d for 12 weeks and then transitioning to 1,200 to 1,500 kcal/d. The coprimary outcomes were changes in intraepidermal nerve fiber density (IENFD) at the distal leg and proximal thigh. Secondary outcomes included nerve conduction studies, Michigan Neuropathy Screening Instrument questionnaire and exam, Quality of Life in Neurological Disorders, and quantitative sensory testing.<h4>Results</h4>Among 131 baseline participants, 72 (mean [SD] age: 50.1 [10.5] years, 51.4% female","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-19T15:39:55.611Z","creation":"2025-04-19T15:39:55.611Z"},"accession":"S-EPMC8612943","cross_references":{"pubmed":["34747574"],"doi":["10.1002/oby.23246"]}}