{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lefebvre MN"],"funding":["NIAID NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["2631-2635"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8612975"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["207(11)"],"pubmed_abstract":["Radiation-attenuated sporozoite (RAS) vaccination offers hope for global malaria control through induction of protective liver-stage-specific memory CD8 T cells. Effective RAS vaccination regimens exist; however, widespread implementation remains unfeasible. A key difficulty resides in the need to administer three or more doses i.v. to achieve sufficient immunity. Strategies to reduce the number of RAS doses are therefore desirable. Here we used mice to model human immune responses to a single, suboptimal weight-normalized RAS dose administered i.v. followed by subunit vaccination to amplify liver-stage-specific memory CD8 T cells. RAS+subunit prime-boost regimens increased the numbers of liver-stage-specific memory CD8 T cells to a level greater than is present after one RAS vaccination. "],"journal":["Journal of immunology (Baltimore, Md. : 1950)"],"pubmed_title":["Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites."],"pmcid":["PMC8612975"],"funding_grant_id":["R01 AI114543","T32 AI007485","P30 CA086862","T32 GM007337","R01 AI042767","T32 GM139776","R01 AI100527","R01 AI085515"],"pubmed_authors":["Hancox LS","Reyes-Sandoval A","Pewe LL","Drewry LL","Lefebvre MN","Harty JT"],"additional_accession":[]},"is_claimable":false,"name":"Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites.","description":"Radiation-attenuated sporozoite (RAS) vaccination offers hope for global malaria control through induction of protective liver-stage-specific memory CD8 T cells. Effective RAS vaccination regimens exist; however, widespread implementation remains unfeasible. A key difficulty resides in the need to administer three or more doses i.v. to achieve sufficient immunity. Strategies to reduce the number of RAS doses are therefore desirable. Here we used mice to model human immune responses to a single, suboptimal weight-normalized RAS dose administered i.v. followed by subunit vaccination to amplify liver-stage-specific memory CD8 T cells. RAS+subunit prime-boost regimens increased the numbers of liver-stage-specific memory CD8 T cells to a level greater than is present after one RAS vaccination. ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T10:17:33.839Z","creation":"2025-04-05T10:17:33.839Z"},"accession":"S-EPMC8612975","cross_references":{"pubmed":["34716185"],"doi":["10.4049/jimmunol.2100818"]}}