{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Avnet S"],"funding":["Italian Association for Cancer Research"],"pagination":["5855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8616358"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(22)"],"pubmed_abstract":["Osteosarcoma is the most frequent primary malignant bone tumour with an impressive tendency to metastasise. Highly proliferative tumour cells release a remarkable amount of protons into the extracellular space that activates the NF-kB inflammatory pathway in adjacent stromal cells. In this study, we further validated the correlation between tumour glycolysis/acidosis and its role in metastases. In patients, at diagnosis, we found high circulating levels of inflammatory mediators (IL6, IL8 and miR-136-5p-containing extracellular vesicles). IL6 serum levels significantly correlated with disease-free survival and <sup>18</sup>F-FDG PET/CT uptake, an indirect measurement of tumour glycolysis and, hence, of acidosis. In vivo subcutaneous and orthotopic models, co-injected with mesenchymal strom"],"journal":["Cancers"],"pubmed_title":["The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma."],"pmcid":["PMC8616358"],"funding_grant_id":["20153","21403"],"pubmed_authors":["Longhi A","Roncuzzi L","Heymann D","Columbaro M","Perut F","Baldini N","Errani C","Dominici M","Di Pompo G","Consolino L","Nanni C","Avnet S","Lipreri MV","Longo DL","Zini N","Righi A","Cortini M","Grisendi G","Lemma S","Golinelli G"],"additional_accession":[]},"is_claimable":false,"name":"The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma.","description":"Osteosarcoma is the most frequent primary malignant bone tumour with an impressive tendency to metastasise. Highly proliferative tumour cells release a remarkable amount of protons into the extracellular space that activates the NF-kB inflammatory pathway in adjacent stromal cells. In this study, we further validated the correlation between tumour glycolysis/acidosis and its role in metastases. In patients, at diagnosis, we found high circulating levels of inflammatory mediators (IL6, IL8 and miR-136-5p-containing extracellular vesicles). IL6 serum levels significantly correlated with disease-free survival and <sup>18</sup>F-FDG PET/CT uptake, an indirect measurement of tumour glycolysis and, hence, of acidosis. In vivo subcutaneous and orthotopic models, co-injected with mesenchymal strom","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-04-08T08:20:24.292Z","creation":"2025-05-29T19:23:31.383Z"},"accession":"S-EPMC8616358","cross_references":{"pubmed":["34831016"],"doi":["10.3390/cancers13225855"]}}