{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garcia-Garcia L"],"funding":["Centre for Biomedical Network Research on Rare Diseases","Instituto de Salud Carlos III","Asociación Candela Riera, Asociación Todos Somos Iván & Fundación Sonrisa de Alex","Asociación Pablo Ugarte","ASION","Asociación Candela Riera, Asociación Todos Somos Iván &amp;amp; Fundación Sonrisa de Alex"],"pagination":["5668"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8616448"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(22)"],"pubmed_abstract":["Ewing sarcoma is a rare pediatric tumor characterized by chromosomal translocations that give rise to aberrant chimeric transcription factors (e.g., EWSR1-FLI1). EWSR1-FLI1 promotes a specific cellular transcriptional program. Therefore, the study of EWSR1-FLI1 target genes is important to identify critical pathways involved in Ewing sarcoma tumorigenesis. In this work, we focused on the transcription factors regulated by EWSR1-FLI1 in Ewing sarcoma. Transcriptomic analysis of the Ewing sarcoma cell line A673 indicated that one of the genes more strongly upregulated by EWSR1-FLI1 was FEZF1 (FEZ family zinc finger protein 1), a transcriptional repressor involved in neural cell identity. The functional characterization of FEZF1 was performed in three Ewing sarcoma cell lines (A673, SK-N-MC, "],"journal":["Cancers"],"pubmed_title":["The Transcription Factor <i>FEZF1</i>, a Direct Target of <i>EWSR1-FLI1</i> in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes."],"pmcid":["PMC8616448"],"funding_grant_id":["TRPV 205/18","U758-Postdoc","PI16CIII/00026","TVP141/17","TVP333-19","PI20CIII/00020","TPI-M 1149/13","DTS18CIII/00005","TVP-1324/15"],"pubmed_authors":["Melero-Fernandez de Mera RM","Gonzalez-Gonzalez L","Fernandez-Tabanera E","Cervera ST","Grunewald TGP","Alonso J","Garcia-Garcia L","Rodriguez-Martin C","Josa S"],"additional_accession":[]},"is_claimable":false,"name":"The Transcription Factor <i>FEZF1</i>, a Direct Target of <i>EWSR1-FLI1</i> in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes.","description":"Ewing sarcoma is a rare pediatric tumor characterized by chromosomal translocations that give rise to aberrant chimeric transcription factors (e.g., EWSR1-FLI1). EWSR1-FLI1 promotes a specific cellular transcriptional program. Therefore, the study of EWSR1-FLI1 target genes is important to identify critical pathways involved in Ewing sarcoma tumorigenesis. In this work, we focused on the transcription factors regulated by EWSR1-FLI1 in Ewing sarcoma. Transcriptomic analysis of the Ewing sarcoma cell line A673 indicated that one of the genes more strongly upregulated by EWSR1-FLI1 was FEZF1 (FEZ family zinc finger protein 1), a transcriptional repressor involved in neural cell identity. The functional characterization of FEZF1 was performed in three Ewing sarcoma cell lines (A673, SK-N-MC, ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-04-08T08:20:47.542Z","creation":"2025-05-29T19:23:32.303Z"},"accession":"S-EPMC8616448","cross_references":{"pubmed":["34830820"],"doi":["10.3390/cancers13225668"]}}