{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pirlog R"],"funding":["Consiliul Naţional pentru Finanţarea Învăţământului Superior"],"pagination":["12491"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8620102"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(22)"],"pubmed_abstract":["Colon cancer-associated transcript 2 (CCAT2) is an intensively studied lncRNA with important regulatory roles in cancer. As such, cumulative studies indicate that CCAT2 displays a high functional versatility due to its direct interaction with multiple RNA binding proteins, transcription factors, and other species of non-coding RNA, especially microRNA. The definitory mechanisms of CCAT2 are its role as a regulator of the TCF7L2 transcription factor, enhancer of MYC expression, and activator of the WNT/β-catenin pathway, as well as a role in promoting and maintaining chromosome instability through the BOP1-AURKB pathway. Additionally, we highlight how the encompassing rs6983267 SNP has been shown to confer CCAT2 with allele-specific functional and structural particularities, such as the all"],"journal":["International journal of molecular sciences"],"pubmed_title":["The Roles of the Colon Cancer Associated Transcript 2 (CCAT2) Long Non-Coding RNA in Cancer: A Comprehensive Characterization of the Tumorigenic and Molecular Functions."],"pmcid":["PMC8620102"],"funding_grant_id":["CNFIS-FDI-2021-0594","grant no. 35/01.09.2016","CNFISFDI-2021-0844"],"pubmed_authors":["Berindan-Neagoe I","Pirlog R","Calin GA","Nutu A","Drula R"],"additional_accession":[]},"is_claimable":false,"name":"The Roles of the Colon Cancer Associated Transcript 2 (CCAT2) Long Non-Coding RNA in Cancer: A Comprehensive Characterization of the Tumorigenic and Molecular Functions.","description":"Colon cancer-associated transcript 2 (CCAT2) is an intensively studied lncRNA with important regulatory roles in cancer. As such, cumulative studies indicate that CCAT2 displays a high functional versatility due to its direct interaction with multiple RNA binding proteins, transcription factors, and other species of non-coding RNA, especially microRNA. The definitory mechanisms of CCAT2 are its role as a regulator of the TCF7L2 transcription factor, enhancer of MYC expression, and activator of the WNT/β-catenin pathway, as well as a role in promoting and maintaining chromosome instability through the BOP1-AURKB pathway. Additionally, we highlight how the encompassing rs6983267 SNP has been shown to confer CCAT2 with allele-specific functional and structural particularities, such as the all","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T13:42:45.542Z","creation":"2022-02-11T13:36:04.628Z"},"accession":"S-EPMC8620102","cross_references":{"pubmed":["34830370"],"doi":["10.3390/ijms222212491"]}}