{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wohnke E"],"funding":["Friedrich-Loeffler-Institut"],"pagination":["2198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8620826"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(11)"],"pubmed_abstract":["African swine fever virus (ASFV), causing an OIE-notifiable viral disease of swine, is spreading over the Eurasian continent and threatening the global pig industry. Here, we conducted the first proteome analysis of ASFV-infected primary porcine monocyte-derived macrophages (moMΦ). In parallel to moMΦ isolated from different pigs, the stable porcine cell line WSL-R was infected with a recombinant of ASFV genotype IX strain \"Kenya1033\". The outcome of the infections was compared via quantitative mass spectrometry (MS)-based proteome analysis. Major differences with respect to the expression of viral proteins or the host cell response were not observed. However, cell-specific expression of some individual viral proteins did occur. The observed modulations of the host proteome were mainly rel"],"journal":["Viruses"],"pubmed_title":["Comparison of the Proteomes of Porcine Macrophages and a Stable Porcine Cell Line after Infection with African Swine Fever Virus."],"pmcid":["PMC8620826"],"funding_grant_id":["ASFV-Research Network"],"pubmed_authors":["Karger A","Hartmann L","Blome S","Fuchs W","Blohm U","Mettenleiter TC","Wohnke E"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of the Proteomes of Porcine Macrophages and a Stable Porcine Cell Line after Infection with African Swine Fever Virus.","description":"African swine fever virus (ASFV), causing an OIE-notifiable viral disease of swine, is spreading over the Eurasian continent and threatening the global pig industry. Here, we conducted the first proteome analysis of ASFV-infected primary porcine monocyte-derived macrophages (moMΦ). In parallel to moMΦ isolated from different pigs, the stable porcine cell line WSL-R was infected with a recombinant of ASFV genotype IX strain \"Kenya1033\". The outcome of the infections was compared via quantitative mass spectrometry (MS)-based proteome analysis. Major differences with respect to the expression of viral proteins or the host cell response were not observed. However, cell-specific expression of some individual viral proteins did occur. The observed modulations of the host proteome were mainly rel","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-04-08T07:02:26.296Z","creation":"2022-02-11T13:35:28.902Z"},"accession":"S-EPMC8620826","cross_references":{"pubmed":["34835004"],"doi":["10.3390/v13112198"]}}