{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zavaglio F"],"funding":["Ministero della Salute","Fondazione Cariplo"],"pagination":["2261"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8621286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(11)"],"pubmed_abstract":["The development and persistence of SARS-CoV-2-specific immune response in immunocompetent (IC) and immunocompromised patients is crucial for long-term protection. Immune response to SARS-CoV-2 infection was analysed in 57 IC and 15 solid organ transplanted (TX) patients. Antibody responses were determined by ELISA and neutralization assay. T-cell response was determined by stimulation with peptide pools of the Spike, Envelope, Membrane, and Nucleocapsid proteins with a 20-h Activation Induced Marker (AIM) and 7-day lymphoproliferative assays. Antibody response was detected at similar levels in IC and TX patients. Anti-Spike IgG, IgA and neutralizing antibodies persisted for at least one year, while anti-Nucleocapsid IgG declined earlier. Patients with pneumonia developed higher antibody le"],"journal":["Viruses"],"pubmed_title":["Robust and Persistent B- and T-Cell Responses after COVID-19 in Immunocompetent and Solid Organ Transplant Recipient Patients."],"pmcid":["PMC8621286"],"funding_grant_id":["CoVIM, no. 2020-1374","BIAS no. 2020-12371760"],"pubmed_authors":["Sammartino JC","Seminari E","Rizzi M","Morosini M","Mallela VR","Minisini R","Baldanti F","Cattadori B","Zavaglio F","Frangipane V","Sainaghi PP","Ferrari A","Rampino T","Di Matteo A","Tonello S","Gregorini M","Gabanti E","Zelini P","Meloni F","Pellegrini C","Asti A","Lilleri D"],"additional_accession":[]},"is_claimable":false,"name":"Robust and Persistent B- and T-Cell Responses after COVID-19 in Immunocompetent and Solid Organ Transplant Recipient Patients.","description":"The development and persistence of SARS-CoV-2-specific immune response in immunocompetent (IC) and immunocompromised patients is crucial for long-term protection. Immune response to SARS-CoV-2 infection was analysed in 57 IC and 15 solid organ transplanted (TX) patients. Antibody responses were determined by ELISA and neutralization assay. T-cell response was determined by stimulation with peptide pools of the Spike, Envelope, Membrane, and Nucleocapsid proteins with a 20-h Activation Induced Marker (AIM) and 7-day lymphoproliferative assays. Antibody response was detected at similar levels in IC and TX patients. Anti-Spike IgG, IgA and neutralizing antibodies persisted for at least one year, while anti-Nucleocapsid IgG declined earlier. Patients with pneumonia developed higher antibody le","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-05-31T23:33:23.446Z","creation":"2025-05-31T23:33:23.446Z"},"accession":"S-EPMC8621286","cross_references":{"pubmed":["34835067"],"doi":["10.3390/v13112261"]}}