{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu F"],"funding":["NHLBI NIH HHS","National Institutes of Health","Prevention and Control Research Incubation Program from Binzhou Medical University","NIH HHS"],"pagination":["1212"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8621576"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(11)"],"pubmed_abstract":["Studies showed that the gastrointestinal (GI) tract is one of the most important pathways for SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19). As SARS-CoV-2 cellular entry depends on the ACE2 receptor and TMPRSS2 priming of the spike protein, it is important to understand the molecular mechanisms through which these two proteins and their cognate transcripts interact and influence the pathogenesis of COVID-19. In this study, we quantified the expression, associations, genetic modulators, and molecular pathways for <i>Tmprss2</i> and <i>Ace2</i> mRNA expressions in GI tissues using a systems genetics approach and the expanded family of highly diverse BXD mouse strains. The results showed that both <i>Tmprss2</i> and <i>Ace2</i> are highly expressed in GI tissues with significan"],"journal":["Journal of personalized medicine"],"pubmed_title":["<i>Ace2</i> and <i>Tmprss2</i> Expressions Are Regulated by <i>Dhx32</i> and Influence the Gastrointestinal Symptoms Caused by SARS-CoV-2."],"pmcid":["PMC8621576"],"funding_grant_id":["R01DK120567","50012305190","R01 HL151438"],"pubmed_authors":["Lu L","Purevjav E","Pierre JF","Gao J","Orgil BO","Black DD","Xu F","Bajpai AK","Li K","Gu Q","Davenport AS","Towbin JA"],"additional_accession":[]},"is_claimable":false,"name":"<i>Ace2</i> and <i>Tmprss2</i> Expressions Are Regulated by <i>Dhx32</i> and Influence the Gastrointestinal Symptoms Caused by SARS-CoV-2.","description":"Studies showed that the gastrointestinal (GI) tract is one of the most important pathways for SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19). As SARS-CoV-2 cellular entry depends on the ACE2 receptor and TMPRSS2 priming of the spike protein, it is important to understand the molecular mechanisms through which these two proteins and their cognate transcripts interact and influence the pathogenesis of COVID-19. In this study, we quantified the expression, associations, genetic modulators, and molecular pathways for <i>Tmprss2</i> and <i>Ace2</i> mRNA expressions in GI tissues using a systems genetics approach and the expanded family of highly diverse BXD mouse strains. The results showed that both <i>Tmprss2</i> and <i>Ace2</i> are highly expressed in GI tissues with significan","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-26T05:27:45.608Z","creation":"2022-02-11T13:34:51.564Z"},"accession":"S-EPMC8621576","cross_references":{"pubmed":["34834564"],"doi":["10.3390/jpm11111212"]}}