{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cappadona C"],"funding":["Banca Intesa San Paolo"],"pagination":["1166"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8622845"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(11)"],"pubmed_abstract":["Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19) pandemic. Besides virus intrinsic characteristics, the host genetic makeup is predicted to account for the extreme clinical heterogeneity of the disease, which is characterized, among other manifestations, by a derangement of hemostasis associated with thromboembolic events. To date, large-scale studies confirmed that genetic predisposition plays a role in COVID-19 severity, pinpointing several susceptibility genes, often characterized by immunologic functions. With these premises, we performed an association study of common variants in 32 hemostatic genes with COVID-19 severity. We investigated 49,845 single-nucleotide polymorphism in a cohort of 332 Italian sever"],"journal":["Journal of personalized medicine"],"pubmed_title":["MEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 Severity."],"pmcid":["PMC8622845"],"funding_grant_id":["-"],"pubmed_authors":["Gerussi A","D'Eugenio D","Corbella P","Papatolo A","Carloni F","Cameroni C","Guerrera L","Ziliotto N","Lopedote L","Franke A","Grondelli MC","Menga LM","Dal Ri G","Smidili A","Tartaglia FC","Asselta R","Duga S","Mariola C","Montorsi G","Bolchini C","Cappadona C","Rimoldi V","Invernizzi P","Di Giorgio SM","Degenhardt F","Bottaro S","Composto A","Matronola GM","Cavadini G","Brenna D","Converso G","Azimonti A","Paraboschi EM","Campanaro G","Marconi E","Brunati A","Pattini L","Laffoucriere G","Tettamanzi G","Profeta L","Rebasti V","Tinelli E","Lando B","Patti R","Maizza B","Tarchi SM","Ciravegna M","Stuani R"],"additional_accession":[]},"is_claimable":false,"name":"MEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 Severity.","description":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19) pandemic. Besides virus intrinsic characteristics, the host genetic makeup is predicted to account for the extreme clinical heterogeneity of the disease, which is characterized, among other manifestations, by a derangement of hemostasis associated with thromboembolic events. To date, large-scale studies confirmed that genetic predisposition plays a role in COVID-19 severity, pinpointing several susceptibility genes, often characterized by immunologic functions. With these premises, we performed an association study of common variants in 32 hemostatic genes with COVID-19 severity. We investigated 49,845 single-nucleotide polymorphism in a cohort of 332 Italian sever","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T11:13:37.25Z","creation":"2022-02-11T13:35:05.247Z"},"accession":"S-EPMC8622845","cross_references":{"pubmed":["34834519"],"doi":["10.3390/jpm11111166"]}}