biostudies-literatureCappadona CBanca Intesa San Paolo1166https://www.ebi.ac.uk/biostudies/studies/S-EPMC8622845biostudies-literatureUnknown11(11)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19) pandemic. Besides virus intrinsic characteristics, the host genetic makeup is predicted to account for the extreme clinical heterogeneity of the disease, which is characterized, among other manifestations, by a derangement of hemostasis associated with thromboembolic events. To date, large-scale studies confirmed that genetic predisposition plays a role in COVID-19 severity, pinpointing several susceptibility genes, often characterized by immunologic functions. With these premises, we performed an association study of common variants in 32 hemostatic genes with COVID-19 severity. We investigated 49,845 single-nucleotide polymorphism in a cohort of 332 Italian severJournal of personalized medicineMEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 Severity.PMC8622845-Gerussi AD'Eugenio DCorbella PPapatolo ACarloni FCameroni CGuerrera LZiliotto NLopedote LFranke AGrondelli MCMenga LMDal Ri GSmidili ATartaglia FCAsselta RDuga SMariola CMontorsi GBolchini CCappadona CRimoldi VInvernizzi PDi Giorgio SMDegenhardt FBottaro SComposto AMatronola GMCavadini GBrenna DConverso GAzimonti AParaboschi EMCampanaro GMarconi EBrunati APattini LLaffoucriere GTettamanzi GProfeta LRebasti VTinelli ELando BPatti RMaizza BTarchi SMCiravegna MStuani RfalseMEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 Severity.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19) pandemic. Besides virus intrinsic characteristics, the host genetic makeup is predicted to account for the extreme clinical heterogeneity of the disease, which is characterized, among other manifestations, by a derangement of hemostasis associated with thromboembolic events. To date, large-scale studies confirmed that genetic predisposition plays a role in COVID-19 severity, pinpointing several susceptibility genes, often characterized by immunologic functions. With these premises, we performed an association study of common variants in 32 hemostatic genes with COVID-19 severity. We investigated 49,845 single-nucleotide polymorphism in a cohort of 332 Italian sever2021-01-01T00:00:00Z2021 Nov2025-04-04T11:13:37.25Z2022-02-11T13:35:05.247ZS-EPMC86228453483451910.3390/jpm11111166