{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ju H"],"funding":["National Natural Science Foundation of China","Shanghai Sailing Program"],"pagination":["1152-1172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8626595"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(11)"],"pubmed_abstract":["<h4>Background</h4>There is increasing evidence that circular RNAs (circRNAs) play a significant role in pathological processes including tumorigenesis. In contrast to exonic circRNAs, which are the most frequently reported circRNAs in cancer so far, the studies of intronic circRNAs have been greatly lagged behind. Here, we aimed to investigate the regulatory role of intronic circRNAs in head and neck squamous cell carcinoma (HNSCC).<h4>Methods</h4>We conducted whole-transcriptome sequencing with four pairs of primary tumor tissues and adjacent normal tissues from HNSCC patients. Then, we characterized circGNG7 expression in HNSCC tissues and cell lines and explored its association with the prognosis of HNSCC patients. We also identified interactions between circGNG7 and functional protein"],"journal":["Cancer communications (London, England)"],"pubmed_title":["A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82."],"pmcid":["PMC8626595"],"funding_grant_id":["19YF1427100","81872185","81902748"],"pubmed_authors":["Ju H","Ren G","Li Z","Hu Z","Huang J","Hu J","Wei D","Zhang X","Guo W","Rui M"],"additional_accession":[]},"is_claimable":false,"name":"A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82.","description":"<h4>Background</h4>There is increasing evidence that circular RNAs (circRNAs) play a significant role in pathological processes including tumorigenesis. In contrast to exonic circRNAs, which are the most frequently reported circRNAs in cancer so far, the studies of intronic circRNAs have been greatly lagged behind. Here, we aimed to investigate the regulatory role of intronic circRNAs in head and neck squamous cell carcinoma (HNSCC).<h4>Methods</h4>We conducted whole-transcriptome sequencing with four pairs of primary tumor tissues and adjacent normal tissues from HNSCC patients. Then, we characterized circGNG7 expression in HNSCC tissues and cell lines and explored its association with the prognosis of HNSCC patients. We also identified interactions between circGNG7 and functional protein","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-08T20:41:50.765Z","creation":"2022-02-11T13:35:13.891Z"},"accession":"S-EPMC8626595","cross_references":{"pubmed":["34498800"],"doi":["10.1002/cac2.12213"]}}