{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeon O"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","National Institutes of Health","NIAMS NIH HHS"],"pagination":["88-98"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8627484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["136"],"pubmed_abstract":["The mechanical properties of the native extracellular matrix play a key role in regulating cell behavior during developmental, healing and homeostatic processes. Since these properties change over time, it may be valuable to have the capacity to dynamically vary the mechanical properties of engineered hydrogels used in tissue engineering strategies to better mimic the dynamic mechanical behavior of native extracellular matrix. However, in situ repeatedly reversible dynamic tuning of hydrogel mechanics is still limited. In this study, we have engineered a hydrogel system with reversible dynamic mechanics using a dual-crosslinkable alginate hydrogel. The effect of reversible mechanical signals on encapsulated stem cells in dynamically tunable hydrogels has been demonstrated. In situ stiffeni"],"journal":["Acta biomaterialia"],"pubmed_title":["Reversible dynamic mechanics of hydrogels for regulation of cellular behavior."],"pmcid":["PMC8627484"],"funding_grant_id":["R01 AR069564","R01 AR066193","R01AR069564","R01AR066193"],"pubmed_authors":["Jeon O","Kim TH","Alsberg E"],"additional_accession":[]},"is_claimable":false,"name":"Reversible dynamic mechanics of hydrogels for regulation of cellular behavior.","description":"The mechanical properties of the native extracellular matrix play a key role in regulating cell behavior during developmental, healing and homeostatic processes. Since these properties change over time, it may be valuable to have the capacity to dynamically vary the mechanical properties of engineered hydrogels used in tissue engineering strategies to better mimic the dynamic mechanical behavior of native extracellular matrix. However, in situ repeatedly reversible dynamic tuning of hydrogel mechanics is still limited. In this study, we have engineered a hydrogel system with reversible dynamic mechanics using a dual-crosslinkable alginate hydrogel. The effect of reversible mechanical signals on encapsulated stem cells in dynamically tunable hydrogels has been demonstrated. In situ stiffeni","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-26T09:48:24.656Z","creation":"2025-04-06T13:07:09.432Z"},"accession":"S-EPMC8627484","cross_references":{"pubmed":["34563721"],"doi":["10.1016/j.actbio.2021.09.032"]}}