biostudies-literatureLex HNational Center for Advancing Translational SciencesUniversity of MichiganNCATS NIH HHSDepression Center, University of MichiganNIMH NIH HHSA. Alfred Taubman Medical Research InstituteNational Institute of Mental Health135-139https://www.ebi.ac.uk/biostudies/studies/S-EPMC8628522biostudies-literatureUnknown291<h4>Background</h4>Electroconvulsive therapy (ECT) is highly effective for treatment-resistant depression (TRD), and previous studies have demonstrated short-term improvements in quality of life (QoL) after ECT.  However, long-term QoL after ECT has not been studied, and the baseline patient characteristics that predict long-term QoL remain unknown.<h4>Methods</h4>Seventy-nine subjects with unipolar or bipolar TRD were enrolled in this prospective longitudinal observational study. Physical, psychological, social, and environmental QoL domains were measured with the abbreviated World Health Organization Quality of Life scale (WHOQOL-BREF) at baseline and every 6 months for up to 2 years after ECT.  Baseline sociodemographic and clinical features were tested for association with long-term QoJournal of affective disordersLong-term quality of life in treatment-resistant depression after electroconvulsive therapy.PMC8628522K23 MH092648K23 MH 092648UL1 TR0004332UL1 TR 000433UL1 TR002538Jensen ELGinsburg YMickey BJLex HNevers SWMaixner DFfalseLong-term quality of life in treatment-resistant depression after electroconvulsive therapy.<h4>Background</h4>Electroconvulsive therapy (ECT) is highly effective for treatment-resistant depression (TRD), and previous studies have demonstrated short-term improvements in quality of life (QoL) after ECT.  However, long-term QoL after ECT has not been studied, and the baseline patient characteristics that predict long-term QoL remain unknown.<h4>Methods</h4>Seventy-nine subjects with unipolar or bipolar TRD were enrolled in this prospective longitudinal observational study. Physical, psychological, social, and environmental QoL domains were measured with the abbreviated World Health Organization Quality of Life scale (WHOQOL-BREF) at baseline and every 6 months for up to 2 years after ECT.  Baseline sociodemographic and clinical features were tested for association with long-term Qo2021-01-01T00:00:00Z2021 Aug2025-04-26T16:34:28.883Z2025-04-06T15:13:01.913ZS-EPMC86285223403883010.1016/j.jad.2021.05.012