biostudies-literaturePolosukhina DBLRD VACrohn's & Colitis Foundation of AmericaNIDDK NIH HHSNCI NIH HHSNIGMS NIH HHSCSRD VA6540-6546https://www.ebi.ac.uk/biostudies/studies/S-EPMC8629429biostudies-literatureUnknown40(47)CCL11, also known as eotaxin-1, is described as an eosinophil chemoattractant, which has been implicated in allergic and Th2 inflammatory diseases. We have reported that CCL11 is significantly increased in the serum of inflammatory bowel disease (IBD) patients, colonic eosinophils are increased and correlate with tissue CCL11 levels in ulcerative colitis patients, and CCL11 is increased in dextran sulfate sodium (DSS)-induced murine colitis. Here, we show that CCL11 is involved in the pathogenesis of DSS-induced colitis and in colon tumorigenesis in the azoxymethane (AOM)-DSS model of colitis-associated carcinogenesis (CAC). Ccl11^-/- mice exposed to DSS then allowed to recover had significantly less body weight loss and a decrease in histologic injury versus wild-type (WT) mice.OncogeneCCL11 exacerbates colitis and inflammation-associated colon tumorigenesis.PMC8629429P01 CA028842T32 DK007673U24 DK059637P30 DK058404P01 CA116087IK2 BX002126703003R01 DK128200P30 CA068485T32 GM008554I01 BX004366P50 CA236733I01 CX002171R01 CA190612Washington MKBarry DPAsim MSingh KHardbower DMCoburn LAGobert APWilson KTPiazuelo MBPolosukhina DAllaman MMfalseCCL11 exacerbates colitis and inflammation-associated colon tumorigenesis.CCL11, also known as eotaxin-1, is described as an eosinophil chemoattractant, which has been implicated in allergic and Th2 inflammatory diseases. We have reported that CCL11 is significantly increased in the serum of inflammatory bowel disease (IBD) patients, colonic eosinophils are increased and correlate with tissue CCL11 levels in ulcerative colitis patients, and CCL11 is increased in dextran sulfate sodium (DSS)-induced murine colitis. Here, we show that CCL11 is involved in the pathogenesis of DSS-induced colitis and in colon tumorigenesis in the azoxymethane (AOM)-DSS model of colitis-associated carcinogenesis (CAC). Ccl11^-/- mice exposed to DSS then allowed to recover had significantly less body weight loss and a decrease in histologic injury versus wild-type (WT) mice.2021-01-01T00:00:00Z2021 Nov2025-04-04T19:57:53.974Z2025-04-04T19:57:53.974ZS-EPMC86294293462571010.1038/s41388-021-02046-3