biostudies-literatureGavazzi FNINDS NIH HHS34-39https://www.ebi.ac.uk/biostudies/studies/S-EPMC8629609biostudies-literatureUnknown125<h4>Background</h4>Leukodystrophies are a rare class of disorders characterized by severe neuromotor disability. There is a strong need for research regarding the functional status of people with leukodystrophy which is limited by the need for in-person assessments of mobility. The purpose of this study is to assess the reliability of the Gross Motor Function Measure-88 (GMFM-88) using telemedicine compared with standard in-person assessments in patients with leukodystrophy.<h4>Methods</h4>A total of 21 subjects with a diagnosis of leukodystrophy (age range = 1.79-52.82 years) were evaluated by in-person and by telemedicine evaluations with the GMFM-88 by physical therapists. Inter-rater reliability was assessed through evaluation of the same subject by two independent raters within a threPediatric neurologyReliability of the Telemedicine Application of the Gross Motor Function Measure-88 in Patients With Leukodystrophy.PMC8629609K23 NS114113U01 NS106845U54 NS115052Glanzman AMLorch SAJan AKHarrington AAdang LVanderver AGavazzi FPierce SRDeMauro SBBallance EShults JKornafel TWaldman ALiu GfalseReliability of the Telemedicine Application of the Gross Motor Function Measure-88 in Patients With Leukodystrophy.<h4>Background</h4>Leukodystrophies are a rare class of disorders characterized by severe neuromotor disability. There is a strong need for research regarding the functional status of people with leukodystrophy which is limited by the need for in-person assessments of mobility. The purpose of this study is to assess the reliability of the Gross Motor Function Measure-88 (GMFM-88) using telemedicine compared with standard in-person assessments in patients with leukodystrophy.<h4>Methods</h4>A total of 21 subjects with a diagnosis of leukodystrophy (age range = 1.79-52.82 years) were evaluated by in-person and by telemedicine evaluations with the GMFM-88 by physical therapists. Inter-rater reliability was assessed through evaluation of the same subject by two independent raters within a thre2021-01-01T00:00:00Z2021 Dec2025-04-25T20:55:43.366Z2025-04-06T08:33:22.889ZS-EPMC86296093462460910.1016/j.pediatrneurol.2021.09.012