biostudies-literatureUnknown20(2)Hashemian L<h4>Background</h4>Type 2 diabetes (T2DM) prevalence has been rapidly increasing in the last decades. T2DM pathogenesis is related to insulin resistance and beta-cell dysfunction. <i>Peroxisome proliferator-activated receptor gamma (PPARG)</i> is concerned about T2DM risk through the involvement in adipocyte differentiation and energy homeostasis. The present study aimed to find the risk associated with a common genetic variant (Pro12Ala) of the <i>PPARG</i> gene in the development of T2DM in a group of the Iranian population.<h4>Methods</h4>Totally, 149 patients with T2DM and 96 healthy individuals were recruited in this case-control study. The genotyping of the genetic variant was carried out using the polymerase chain reaction (PCR) followed by Sanger sequencing.<h4>Results</h4>No significant difference is observed between the CG and GG genotypes frequency of the <i>PPARG</i> variant (<i>P</i> = 0.17) in T2DM patient and the control groups. Furthermore, the frequency of the G allele was similar between case and control groups. The Pro12Ala variant may decrease the risk of diabetic retinopathy (DR) which was not statistically significant. Furthermore, the Pro12Ala variant caused a 27% increase in the risk of diabetes nephropathy (DN) among patients with T2DM but was not significant.<h4>Conclusions</h4>Our findings showed that the <i>PPARG</i> variant could not impact on T2DM development and its complications.Journal of diabetes and metabolic disorders1385-1390https://www.ebi.ac.uk/biostudies/studies/S-EPMC8630345biostudies-literatureThe role of the PPARG (Pro12Ala) common genetic variant on type 2 diabetes mellitus risk.PMC8630345Hasanzad MSarhangi NAghaei Meybodi HRAfshari MHashemian LfalseThe role of the PPARG (Pro12Ala) common genetic variant on type 2 diabetes mellitus risk.<h4>Background</h4>Type 2 diabetes (T2DM) prevalence has been rapidly increasing in the last decades. T2DM pathogenesis is related to insulin resistance and beta-cell dysfunction. <i>Peroxisome proliferator-activated receptor gamma (PPARG)</i> is concerned about T2DM risk through the involvement in adipocyte differentiation and energy homeostasis. The present study aimed to find the risk associated with a common genetic variant (Pro12Ala) of the <i>PPARG</i> gene in the development of T2DM in a group of the Iranian population.<h4>Methods</h4>Totally, 149 patients with T2DM and 96 healthy individuals were recruited in this case-control study. The genotyping of the genetic variant was carried out using the polymerase chain reaction (PCR) followed by Sanger sequencing.<h4>Results</h4>No significant difference is observed between the CG and GG genotypes frequency of the <i>PPARG</i> variant (<i>P</i> = 0.17) in T2DM patient and the control groups. Furthermore, the frequency of the G allele was similar between case and control groups. The Pro12Ala variant may decrease the risk of diabetic retinopathy (DR) which was not statistically significant. Furthermore, the Pro12Ala variant caused a 27% increase in the risk of diabetes nephropathy (DN) among patients with T2DM but was not significant.<h4>Conclusions</h4>Our findings showed that the <i>PPARG</i> variant could not impact on T2DM development and its complications.2021-01-01T00:00:00Z2021 Dec2024-11-15T20:17:15.932Z2024-11-15T20:17:15.932ZS-EPMC86303453490079010.1007/s40200-021-00872-6