biostudies-literatureUnknown176(2)Huang JX<h4>Importance</h4>Diabetic kidney disease is among the most important causes of end-stage kidney disease worldwide. Risk factors for diabetic kidney disease remain incompletely defined. Recent studies document a high frequency of acute kidney injury (AKI) during diabetic ketoacidosis (DKA) in children, raising the question of whether these AKI episodes might contribute to future risk of diabetic kidney disease.<h4>Objective</h4>To determine whether episodes of AKI occurring during DKA in children are associated with increased risk of development of microalbuminuria.<h4>Design, setting, and participants</h4>This retrospective review of medical records included children with type 1 diabetes with 1 or more urine albumin levels measured during routine diabetes care from 2 university-affiliateJAMA pediatrics169-175https://www.ebi.ac.uk/biostudies/studies/S-EPMC8630664biostudies-literatureAssociation of Acute Kidney Injury During Diabetic Ketoacidosis With Risk of Microalbuminuria in Children With Type 1 Diabetes.PMC8630664Huang JXMyers SKuppermann NRamesh JPitts CLoomba LGlaser NCasper TCfalseAssociation of Acute Kidney Injury During Diabetic Ketoacidosis With Risk of Microalbuminuria in Children With Type 1 Diabetes.<h4>Importance</h4>Diabetic kidney disease is among the most important causes of end-stage kidney disease worldwide. Risk factors for diabetic kidney disease remain incompletely defined. Recent studies document a high frequency of acute kidney injury (AKI) during diabetic ketoacidosis (DKA) in children, raising the question of whether these AKI episodes might contribute to future risk of diabetic kidney disease.<h4>Objective</h4>To determine whether episodes of AKI occurring during DKA in children are associated with increased risk of development of microalbuminuria.<h4>Design, setting, and participants</h4>This retrospective review of medical records included children with type 1 diabetes with 1 or more urine albumin levels measured during routine diabetes care from 2 university-affiliate2022-01-01T00:00:00Z2022 Feb2025-04-21T16:11:41.153Z2025-04-21T16:11:41.153ZS-EPMC86306643484290810.1001/jamapediatrics.2021.5038