biostudies-literatureLee KLLottery Health New ZealandMaurice Wilkins Centre for Molecular BioDiscoveryMinistry of Business, Innovation and EmploymentHealth Research Council of New Zealand14-22https://www.ebi.ac.uk/biostudies/studies/S-EPMC8632304biostudies-literatureUnknown14(1)Pancreatic islet-cell function and volume are both key determinants of the maintenance of metabolic health. Insulin resistance and islet-cell dysfunction often occur in the earlier stages of type 2 diabetes (T2D) progression. The ability of the islet cells to respond to insulin resistance by increasing hormone output accompanied by increased islet-cell volume is key to maintaining blood glucose control and preventing further disease progression. Eventual β-cell loss is the main driver of full-blown T2D and insulin-dependency. Researchers are targeting T2D with approaches that include those aimed at enhancing the function of the patient's existing β-cell population, or replacing islet β-cells. Another approach is to look for agents that enhance the natural capacity of the β-cell population IsletsVesiculin derived from IGF-II drives increased islet cell mass in a mouse model of pre-diabetes.PMC863230403/1903626585UOAX9902; PMIX0201; UOAX08153602434Li XMontgomery KAitken JFWilliams GMCooper GJSLee KLBrimble MAHsu HLfalseVesiculin derived from IGF-II drives increased islet cell mass in a mouse model of pre-diabetes.Pancreatic islet-cell function and volume are both key determinants of the maintenance of metabolic health. Insulin resistance and islet-cell dysfunction often occur in the earlier stages of type 2 diabetes (T2D) progression. The ability of the islet cells to respond to insulin resistance by increasing hormone output accompanied by increased islet-cell volume is key to maintaining blood glucose control and preventing further disease progression. Eventual β-cell loss is the main driver of full-blown T2D and insulin-dependency. Researchers are targeting T2D with approaches that include those aimed at enhancing the function of the patient's existing β-cell population, or replacing islet β-cells. Another approach is to look for agents that enhance the natural capacity of the β-cell population 2022-01-01T00:00:00Z2022 Jan2025-04-26T16:04:43.623Z2022-02-11T13:59:51.326ZS-EPMC86323043463295910.1080/19382014.2021.1982326