{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["George MD"],"funding":["NIAMS NIH HHS"],"pagination":["65-74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8633063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(1)"],"pubmed_abstract":["<h4>Background</h4>Low-dose glucocorticoids are commonly used in the treatment of rheumatoid arthritis (RA). Observational studies have found an increased risk of serious infection associated with low-dose glucocorticoids, but concerns about residual confounding remain.<h4>Methods</h4>We identified adults with RA on stable immunomodulatory therapy for >6 months receiving no glucocorticoids or ≤5 mg/day using Medicare data from 2006 to 2015. We used provider preference for glucocorticoids as an instrumental variable (IV) to assess associations between low-dose glucocorticoid use and the risk of infection requiring hospitalization using a cause-specific proportional hazards model.<h4>Results</h4>We identified 163,603 qualifying treatment episodes among 120,656 patients. Glucocorticoids ≤5 mg"],"journal":["Epidemiology (Cambridge, Mass.)"],"pubmed_title":["Risk of Serious Infection With Low-dose Glucocorticoids in Patients With Rheumatoid Arthritis: An Instrumental Variable Analysis."],"pmcid":["PMC8633063"],"funding_grant_id":["K23 AR073931"],"pubmed_authors":["Hsu JY","Xie F","Chen L","Baker JF","Curtis JR","Hennessy S","George MD"],"additional_accession":[]},"is_claimable":false,"name":"Risk of Serious Infection With Low-dose Glucocorticoids in Patients With Rheumatoid Arthritis: An Instrumental Variable Analysis.","description":"<h4>Background</h4>Low-dose glucocorticoids are commonly used in the treatment of rheumatoid arthritis (RA). Observational studies have found an increased risk of serious infection associated with low-dose glucocorticoids, but concerns about residual confounding remain.<h4>Methods</h4>We identified adults with RA on stable immunomodulatory therapy for >6 months receiving no glucocorticoids or ≤5 mg/day using Medicare data from 2006 to 2015. We used provider preference for glucocorticoids as an instrumental variable (IV) to assess associations between low-dose glucocorticoid use and the risk of infection requiring hospitalization using a cause-specific proportional hazards model.<h4>Results</h4>We identified 163,603 qualifying treatment episodes among 120,656 patients. Glucocorticoids ≤5 mg","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-04T13:40:20.534Z","creation":"2025-04-04T13:40:20.534Z"},"accession":"S-EPMC8633063","cross_references":{"pubmed":["34561348"],"doi":["10.1097/ede.0000000000001422","10.1097/EDE.0000000000001422"]}}