{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cercek A"],"funding":["Precision, Interception and Prevention Program at MSK","Romeo Milio Lynch Syndrome Foundation","Cancer is a program of the Entertainment Industry Foundation administered by the American Association for Cancer Research","National Cancer Institute","NCI NIH HHS","Stand Up to Cancer Colorectal Cancer Dream Team Translational Research","National Institutes of Health","NIGMS NIH HHS","NIH HHS","Marie-Josée and Henry R. Kravis Center for Molecular Oncology"],"pagination":["1683-1692"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8634406"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["113(12)"],"pubmed_abstract":["<h4>Background</h4>The causative factors for the recent increase in early-onset colorectal cancer (EO-CRC) incidence are unknown. We sought to determine if early-onset disease is clinically or genomically distinct from average-onset colorectal cancer (AO-CRC).<h4>Methods</h4>Clinical, histopathologic, and genomic characteristics of EO-CRC patients (2014-2019), divided into age 35 years and younger and 36-49 years at diagnosis, were compared with AO-CRC (50 years and older). Patients with mismatch repair deficient tumors, CRC-related hereditary syndromes, and inflammatory bowel disease were excluded from all but the germline analysis. All statistical tests were 2-sided.<h4>Results</h4>In total, 759 patients with EO-CRC (35 years, n = 151; 36-49 years, n = 608) and AO-CRC (n = 687) were incl"],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers."],"pmcid":["PMC8634406"],"funding_grant_id":["R25 CA233208","SU2C-AACR-DT22-17","P30 CA008748","K08 CA230213","T32 GM132083","T32 GM132083; R25 CA233208"],"pubmed_authors":["Bandlamudi C","Zhang L","Markowitz A","Birsoy O","Offit K","Robson M","Solit D","Joseph V","Varghese A","Reidy-Lagunes D","Yaeger R","Galle J","Guillem J","Diaz LA","Cercek A","Smith JJ","Maio A","Schultz N","Segal N","Srinivasan P","Taylor B","Kemeny N","Ganesh K","Mendelsohn R","Stadler ZK","Mandelker D","Belanfanti K","Aguilar JG","Lumish MA","Nash G","Walch H","Fernandes GDS","Tejada PR","Paty PB","Kemel Y","Steinruecke F","Salo-Mullen E","Berger M","Mondaca S","Connell L","Saltz LB","Vakiani E","Chatila WK","Shia J","Krishnan A","Weiser M","Palmaira L"],"additional_accession":[]},"is_claimable":false,"name":"A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers.","description":"<h4>Background</h4>The causative factors for the recent increase in early-onset colorectal cancer (EO-CRC) incidence are unknown. We sought to determine if early-onset disease is clinically or genomically distinct from average-onset colorectal cancer (AO-CRC).<h4>Methods</h4>Clinical, histopathologic, and genomic characteristics of EO-CRC patients (2014-2019), divided into age 35 years and younger and 36-49 years at diagnosis, were compared with AO-CRC (50 years and older). Patients with mismatch repair deficient tumors, CRC-related hereditary syndromes, and inflammatory bowel disease were excluded from all but the germline analysis. All statistical tests were 2-sided.<h4>Results</h4>In total, 759 patients with EO-CRC (35 years, n = 151; 36-49 years, n = 608) and AO-CRC (n = 687) were incl","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-09T03:11:33.68Z","creation":"2025-04-19T23:12:49.623Z"},"accession":"S-EPMC8634406","cross_references":{"pubmed":["34405229"],"doi":["10.1093/jnci/djab124"]}}