biostudies-literatureUnknown12Yang MPolysaccharide is one of the main active ingredients of <i>Polygonatum kingianum</i>, which has been proven to regulate the balance of gut microbiota. For the first time, this study focused on the regulation of polysaccharides from <i>Polygonatum kingianum</i> (PS) on <i>Lactobacillus faecis</i>, a specific probiotic in the intestinal tract. PS effectively promoted the biomass, biofilm and acetic acid production in <i>L. faecis</i> 2-84, and enhanced quorum sensing (QS) signaling. The characteristics of gene sequence were analyzed using genomics approaches, and <i>L. faecis</i> 2-84 was found to encode 18 genes that are closely related to QS and 10 genes related to short-chain fatty acids (SCFAs). Additionally, transcriptome and proteome analysis demonstrated that PS could promote the QS sFrontiers in microbiology758870https://www.ebi.ac.uk/biostudies/studies/S-EPMC8635744biostudies-literatureInfluence of Polysaccharides From <i>Polygonatum kingianum</i> on Short-Chain Fatty Acid Production and Quorum Sensing in <i>Lactobacillus faecis</i>.PMC8635744Meng FYang XZhang FLi JZhang ZTao YYang MGu WLi FFu LWang XYu JfalseInfluence of Polysaccharides From <i>Polygonatum kingianum</i> on Short-Chain Fatty Acid Production and Quorum Sensing in <i>Lactobacillus faecis</i>.Polysaccharide is one of the main active ingredients of <i>Polygonatum kingianum</i>, which has been proven to regulate the balance of gut microbiota. For the first time, this study focused on the regulation of polysaccharides from <i>Polygonatum kingianum</i> (PS) on <i>Lactobacillus faecis</i>, a specific probiotic in the intestinal tract. PS effectively promoted the biomass, biofilm and acetic acid production in <i>L. faecis</i> 2-84, and enhanced quorum sensing (QS) signaling. The characteristics of gene sequence were analyzed using genomics approaches, and <i>L. faecis</i> 2-84 was found to encode 18 genes that are closely related to QS and 10 genes related to short-chain fatty acids (SCFAs). Additionally, transcriptome and proteome analysis demonstrated that PS could promote the QS s2021-01-01T00:00:00Z20212026-04-08T07:52:59.675Z2022-02-11T14:15:20.656ZS-EPMC86357443486788710.3389/fmicb.2021.758870