biostudies-literatureUnknown29(12)Qiu WShandong Province Natural Science FoundationNational Natural Science Foundation of ChinaShandong UniversityTaishan Scholar Foundation of Shandong ProvinceGlioma is a heterogeneous cellular environment in which immune cells play critical roles in tumor progression. Myeloid-derived suppressor cells (MDSCs) contribute to the formation of the immunosuppressive microenvironment of glioma; however, how glioma cells interact with MDSCs and how this interaction affects the function of other immune cells are unclear. Glioma cells can systemically communicate with immune cells via the secretion of exosomes, which contain microRNAs (miRNAs). Leveraging miRNA sequencing of exosomes, we identified enrichment of miR-1246 in glioma-derived exosomes and exosomes isolated from the cerebrospinal fluid (CSF) of glioma patients. We demonstrated that miR-1246 drives the differentiation and activation of MDSCs in a dual specificity phosphatase 3 (DUSP3)/extracelMolecular therapy : the journal of the American Society of Gene Therapy3449-3464https://www.ebi.ac.uk/biostudies/studies/S-EPMC8636176biostudies-literatureExosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells.PMC8636176Li GPan ZGuo XDeng LZhang SWang JGuo QQiu WZhao SChen ZZhao RZhang ZWang SQi YLi BXue HQian MfalseExosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells.Glioma is a heterogeneous cellular environment in which immune cells play critical roles in tumor progression. Myeloid-derived suppressor cells (MDSCs) contribute to the formation of the immunosuppressive microenvironment of glioma; however, how glioma cells interact with MDSCs and how this interaction affects the function of other immune cells are unclear. Glioma cells can systemically communicate with immune cells via the secretion of exosomes, which contain microRNAs (miRNAs). Leveraging miRNA sequencing of exosomes, we identified enrichment of miR-1246 in glioma-derived exosomes and exosomes isolated from the cerebrospinal fluid (CSF) of glioma patients. We demonstrated that miR-1246 drives the differentiation and activation of MDSCs in a dual specificity phosphatase 3 (DUSP3)/extracel2021-01-01T00:00:00Z2021 Dec2025-04-26T09:46:18.665Z2025-04-06T13:08:10.609ZS-EPMC86361763421789210.1016/j.ymthe.2021.06.023