{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wynne N"],"funding":["NEI NIH HHS","National Eye Institute","Research to Prevent Blindness","Foundation Fighting Blindness","FDA HHS"],"pagination":["100920"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8639282"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["83"],"pubmed_abstract":["Adaptive optics scanning light ophthalmoscopy (AOSLO) allows visualization of the living human retina with exquisite single-cell resolution. This technology has improved our understanding of normal retinal structure and revealed pathophysiological details of a number of retinal diseases. Despite the remarkable capabilities of AOSLO, it has not seen the widespread commercial adoption and mainstream clinical success of other modalities developed in a similar time frame. Nevertheless, continued advancements in AOSLO hardware and software have expanded use to a broader range of patients. Current devices enable imaging of a number of different retinal cell types, with recent improvements in stimulus and detection schemes enabling monitoring of retinal function, microscopic structural changes, a"],"journal":["Progress in retinal and eye research"],"pubmed_title":["Promises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO)."],"pmcid":["PMC8639282"],"funding_grant_id":["P30 EY002162","U01 EY025477","R01 EY021237","U24 EY029891","R01 EY023591","R01 FD004100","R01 EY017607"],"pubmed_authors":["Duncan JL","Carroll J","Wynne N"],"additional_accession":[]},"is_claimable":false,"name":"Promises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO).","description":"Adaptive optics scanning light ophthalmoscopy (AOSLO) allows visualization of the living human retina with exquisite single-cell resolution. This technology has improved our understanding of normal retinal structure and revealed pathophysiological details of a number of retinal diseases. Despite the remarkable capabilities of AOSLO, it has not seen the widespread commercial adoption and mainstream clinical success of other modalities developed in a similar time frame. Nevertheless, continued advancements in AOSLO hardware and software have expanded use to a broader range of patients. Current devices enable imaging of a number of different retinal cell types, with recent improvements in stimulus and detection schemes enabling monitoring of retinal function, microscopic structural changes, a","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-04-19T10:49:47.564Z","creation":"2025-04-19T10:49:47.564Z"},"accession":"S-EPMC8639282","cross_references":{"pubmed":["33161127"],"doi":["10.1016/j.preteyeres.2020.100920"]}}