biostudies-literatureWynne NNEI NIH HHSNational Eye InstituteResearch to Prevent BlindnessFoundation Fighting BlindnessFDA HHS100920https://www.ebi.ac.uk/biostudies/studies/S-EPMC8639282biostudies-literatureUnknown83Adaptive optics scanning light ophthalmoscopy (AOSLO) allows visualization of the living human retina with exquisite single-cell resolution. This technology has improved our understanding of normal retinal structure and revealed pathophysiological details of a number of retinal diseases. Despite the remarkable capabilities of AOSLO, it has not seen the widespread commercial adoption and mainstream clinical success of other modalities developed in a similar time frame. Nevertheless, continued advancements in AOSLO hardware and software have expanded use to a broader range of patients. Current devices enable imaging of a number of different retinal cell types, with recent improvements in stimulus and detection schemes enabling monitoring of retinal function, microscopic structural changes, aProgress in retinal and eye researchPromises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO).PMC8639282P30 EY002162U01 EY025477R01 EY021237U24 EY029891R01 EY023591R01 FD004100R01 EY017607Duncan JLCarroll JWynne NfalsePromises and pitfalls of evaluating photoreceptor-based retinal disease with adaptive optics scanning light ophthalmoscopy (AOSLO).Adaptive optics scanning light ophthalmoscopy (AOSLO) allows visualization of the living human retina with exquisite single-cell resolution. This technology has improved our understanding of normal retinal structure and revealed pathophysiological details of a number of retinal diseases. Despite the remarkable capabilities of AOSLO, it has not seen the widespread commercial adoption and mainstream clinical success of other modalities developed in a similar time frame. Nevertheless, continued advancements in AOSLO hardware and software have expanded use to a broader range of patients. Current devices enable imaging of a number of different retinal cell types, with recent improvements in stimulus and detection schemes enabling monitoring of retinal function, microscopic structural changes, a2021-01-01T00:00:00Z2021 Jul2025-04-19T10:49:47.564Z2025-04-19T10:49:47.564ZS-EPMC86392823316112710.1016/j.preteyeres.2020.100920