{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang YF"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders","Deutsche Forschungsgemeinschaft","NIDA NIH HHS","Whitehall Foundation","NIDCD NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","NINDS NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"],"pagination":["1699-1710"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8639805"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(12)"],"pubmed_abstract":["The striatum comprises multiple subdivisions and neural circuits that differentially control motor output. The islands of Calleja (IC) contain clusters of densely packed granule cells situated in the ventral striatum, predominantly in the olfactory tubercle (OT). Characterized by expression of the D3 dopamine receptor, the IC are evolutionally conserved, but have undefined functions. Here, we show that optogenetic activation of OT D3 neurons robustly initiates self-grooming in mice while suppressing other ongoing behaviors. Conversely, optogenetic inhibition of these neurons halts ongoing grooming, and genetic ablation reduces spontaneous grooming. Furthermore, OT D3 neurons show increased activity before and during grooming and influence local striatal output via synaptic connections with"],"journal":["Nature neuroscience"],"pubmed_title":["Ventral striatal islands of Calleja neurons control grooming in mice."],"pmcid":["PMC8639805"],"funding_grant_id":["R01 DA049545","F31 MH124372","R01 DA049449","R01MH115030","R01 DC014443","R01DC006213","269953372/GRK2150","R01 MH115030","R01 NS117061","368482240/GRK2416","R01 MH118369","R01DA049449","for OCD Research","F31 DC017054","R21 DC019193","R01DA049545","R01DC014443","R01 DC006213","F32 DC018452","R01 DC016519","R01DC016519"],"pubmed_authors":["Stegmaier J","Janke E","Ma M","Bhattarai JP","Goldstein N","Cranfill SL","Moberly AH","Schreck M","Zhang YF","Betley JN","Fleck D","Wesson DW","Fuccillo MV","Vargas Cifuentes L","Luo W","Wright KN","Jiang C","Spehr M","Arenkiel BR","Mohrhardt J","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Ventral striatal islands of Calleja neurons control grooming in mice.","description":"The striatum comprises multiple subdivisions and neural circuits that differentially control motor output. The islands of Calleja (IC) contain clusters of densely packed granule cells situated in the ventral striatum, predominantly in the olfactory tubercle (OT). Characterized by expression of the D3 dopamine receptor, the IC are evolutionally conserved, but have undefined functions. Here, we show that optogenetic activation of OT D3 neurons robustly initiates self-grooming in mice while suppressing other ongoing behaviors. Conversely, optogenetic inhibition of these neurons halts ongoing grooming, and genetic ablation reduces spontaneous grooming. Furthermore, OT D3 neurons show increased activity before and during grooming and influence local striatal output via synaptic connections with","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-06-01T01:11:16.194Z","creation":"2025-02-18T23:37:04.819Z"},"accession":"S-EPMC8639805","cross_references":{"pubmed":["34795450"],"doi":["10.1038/s41593-021-00952-z"]}}