{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sciacchitano S"],"funding":["ministero dell'istruzione, dell'università e della ricerca","associazione italiana per la ricerca sul cancro","ministero dell’istruzione, dell’università e della ricerca"],"pagination":["491"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8640710"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the severity the disease. However, the exact mechanism through which thyroid hormones influence the course of COVID-19, as well as that of many other critical illnesses, is not clear yet and treatment with T4, T3 or a combination of both is still controversial. Aim of this study was to analyze body composition in COVID-19 patients in search of possible correlation with the thyroid function.<h4>Methods and findings</h4>We report here our experience performed in 74 critically ill COVID-19 patients hospitalized in the intensive care unit (ICU) of our University Hospital in Rom"],"journal":["Journal of translational medicine"],"pubmed_title":["Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium."],"pmcid":["PMC8640710"],"funding_grant_id":["Prot. 2017HWTP2K","PRIN 2017","IG24451"],"pubmed_authors":["Morgante A","Petrella L","Alessandri E","De Biase L","Marcolongo A","Salehi LB","Negro A","Lavra L","De Vitis C","Loffredo C","Magi F","Sciacchitano S","Mancini R","Alampi D","Anibaldi P","Ulivieri A","Rocco M","Capalbo C","Napoli C","Salvati V","Coluzzi F","Merlo L"],"additional_accession":[]},"is_claimable":false,"name":"Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium.","description":"<h4>Background</h4>Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the severity the disease. However, the exact mechanism through which thyroid hormones influence the course of COVID-19, as well as that of many other critical illnesses, is not clear yet and treatment with T4, T3 or a combination of both is still controversial. Aim of this study was to analyze body composition in COVID-19 patients in search of possible correlation with the thyroid function.<h4>Methods and findings</h4>We report here our experience performed in 74 critically ill COVID-19 patients hospitalized in the intensive care unit (ICU) of our University Hospital in Rom","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-26T13:43:39.754Z","creation":"2022-02-11T14:05:12.766Z"},"accession":"S-EPMC8640710","cross_references":{"pubmed":["34861865"],"doi":["10.1186/s12967-021-03163-z"]}}