biostudies-literatureSciacchitano Sministero dell'istruzione, dell'università e della ricercaassociazione italiana per la ricerca sul cancroministero dell’istruzione, dell’università e della ricerca491https://www.ebi.ac.uk/biostudies/studies/S-EPMC8640710biostudies-literatureUnknown19(1)<h4>Background</h4>Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the severity the disease. However, the exact mechanism through which thyroid hormones influence the course of COVID-19, as well as that of many other critical illnesses, is not clear yet and treatment with T4, T3 or a combination of both is still controversial. Aim of this study was to analyze body composition in COVID-19 patients in search of possible correlation with the thyroid function.<h4>Methods and findings</h4>We report here our experience performed in 74 critically ill COVID-19 patients hospitalized in the intensive care unit (ICU) of our University Hospital in RomJournal of translational medicineNonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium.PMC8640710Prot. 2017HWTP2KPRIN 2017IG24451Morgante APetrella LAlessandri EDe Biase LMarcolongo ASalehi LBNegro ALavra LDe Vitis CLoffredo CMagi FSciacchitano SMancini RAlampi DAnibaldi PUlivieri ARocco MCapalbo CNapoli CSalvati VColuzzi FMerlo LfalseNonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium.<h4>Background</h4>Nonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is frequently observed in COVID-19 patients too and it is correlated with the severity the disease. However, the exact mechanism through which thyroid hormones influence the course of COVID-19, as well as that of many other critical illnesses, is not clear yet and treatment with T4, T3 or a combination of both is still controversial. Aim of this study was to analyze body composition in COVID-19 patients in search of possible correlation with the thyroid function.<h4>Methods and findings</h4>We report here our experience performed in 74 critically ill COVID-19 patients hospitalized in the intensive care unit (ICU) of our University Hospital in Rom2021-01-01T00:00:00Z2021 Dec2025-04-26T13:43:39.754Z2022-02-11T14:05:12.766ZS-EPMC86407103486186510.1186/s12967-021-03163-z