{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(11)"],"submitter":["Chai N"],"pubmed_abstract":["Our previous studies indicated that the extract of Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) had potent anticancer activities by significantly inhibiting intestinal tumor development in <i>Apc<sup>Min/+</sup></i> mice. However, knowledge regarding the mechanism and effect of YYFZBJS in the prevention of colorectal cancer is limited. In this study, we aim to investigate the preventive effects of YYFZBJS in <i>enterotoxigenic Bacteroides fragilis</i> (ETBF)-colonized mice with azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced tumorigenesis. First, the colonic tissues of the AOM/DSS mouse models were collected for biomedical analysis, and gut microbiota profiling was detected post YYFZBJS treatment using a 16S rRNA gene sequencing. Then, antibiotic solution (Abx) mice were acclimated with AOM"],"journal":["American journal of cancer research"],"pagination":["5338-5357"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8640793"],"repository":["biostudies-literature"],"pubmed_title":["YYFZBJS inhibits colorectal tumorigenesis by remodeling gut microbiota and influence on M2 macrophage polarization <i>in vivo</i> and <i>in vitro</i>."],"pmcid":["PMC8640793"],"pubmed_authors":["Chai N","Xiong Y","Yao Y","Zhang Y","Sui H","Shi W","Zhu H","Cheng Y"],"additional_accession":[]},"is_claimable":false,"name":"YYFZBJS inhibits colorectal tumorigenesis by remodeling gut microbiota and influence on M2 macrophage polarization <i>in vivo</i> and <i>in vitro</i>.","description":"Our previous studies indicated that the extract of Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) had potent anticancer activities by significantly inhibiting intestinal tumor development in <i>Apc<sup>Min/+</sup></i> mice. However, knowledge regarding the mechanism and effect of YYFZBJS in the prevention of colorectal cancer is limited. In this study, we aim to investigate the preventive effects of YYFZBJS in <i>enterotoxigenic Bacteroides fragilis</i> (ETBF)-colonized mice with azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced tumorigenesis. First, the colonic tissues of the AOM/DSS mouse models were collected for biomedical analysis, and gut microbiota profiling was detected post YYFZBJS treatment using a 16S rRNA gene sequencing. Then, antibiotic solution (Abx) mice were acclimated with AOM","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-19T10:43:48.733Z","creation":"2022-02-11T13:51:12.861Z"},"accession":"S-EPMC8640793","cross_references":{"pubmed":["34873464"]}}