biostudies-literatureUnknown11(11)Chai NOur previous studies indicated that the extract of Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) had potent anticancer activities by significantly inhibiting intestinal tumor development in <i>Apc^Min/+</i> mice. However, knowledge regarding the mechanism and effect of YYFZBJS in the prevention of colorectal cancer is limited. In this study, we aim to investigate the preventive effects of YYFZBJS in <i>enterotoxigenic Bacteroides fragilis</i> (ETBF)-colonized mice with azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced tumorigenesis. First, the colonic tissues of the AOM/DSS mouse models were collected for biomedical analysis, and gut microbiota profiling was detected post YYFZBJS treatment using a 16S rRNA gene sequencing. Then, antibiotic solution (Abx) mice were acclimated with AOMAmerican journal of cancer research5338-5357https://www.ebi.ac.uk/biostudies/studies/S-EPMC8640793biostudies-literatureYYFZBJS inhibits colorectal tumorigenesis by remodeling gut microbiota and influence on M2 macrophage polarization <i>in vivo</i> and <i>in vitro</i>.PMC8640793Chai NXiong YYao YZhang YSui HShi WZhu HCheng YfalseYYFZBJS inhibits colorectal tumorigenesis by remodeling gut microbiota and influence on M2 macrophage polarization <i>in vivo</i> and <i>in vitro</i>.Our previous studies indicated that the extract of Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) had potent anticancer activities by significantly inhibiting intestinal tumor development in <i>Apc^Min/+</i> mice. However, knowledge regarding the mechanism and effect of YYFZBJS in the prevention of colorectal cancer is limited. In this study, we aim to investigate the preventive effects of YYFZBJS in <i>enterotoxigenic Bacteroides fragilis</i> (ETBF)-colonized mice with azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced tumorigenesis. First, the colonic tissues of the AOM/DSS mouse models were collected for biomedical analysis, and gut microbiota profiling was detected post YYFZBJS treatment using a 16S rRNA gene sequencing. Then, antibiotic solution (Abx) mice were acclimated with AOM2021-01-01T00:00:00Z20212025-04-19T10:43:48.733Z2022-02-11T13:51:12.861ZS-EPMC864079334873464