biostudies-literatureUnknown4Airaksinen L<h4>Purpose and objectives</h4>Given their role in homing immune cells to the intestine, CC motif chemokine receptor 9 (CCR9) and its specific ligand CC motif chemokine ligand 25 (CCL25) are interesting candidate genes for celiac disease. These genes are located in regions previously shown to be associated with or linked to celiac disease, but no investigations on their association with various celiac disease phenotypes have so far been conducted. Here we studied such associations of both genotyped and imputed single nucleotide polymorphisms (SNPs) with either regulatory function or exonic location of the <i>CCR9</i> and <i>CCL25</i> loci.<h4>Results</h4>Exploiting a carefully phenotyped cohort of 625 celiac disease patients and 1817 non-celiac controls, we identified that multiple SNPs wiJournal of translational autoimmunity100128https://www.ebi.ac.uk/biostudies/studies/S-EPMC8640869biostudies-literatureDissecting the contribution of single nucleotide polymorphisms in <i>CCR9</i> and <i>CCL25</i> genomic regions to the celiac disease phenotype.PMC8640869Saavalainen PMaki MShcherban AKaukinen KAiraksinen LCerqueira JXLindfors KHuhtala HKilpelainen EKurppa KPalotie AYohannes DAfalseDissecting the contribution of single nucleotide polymorphisms in <i>CCR9</i> and <i>CCL25</i> genomic regions to the celiac disease phenotype.<h4>Purpose and objectives</h4>Given their role in homing immune cells to the intestine, CC motif chemokine receptor 9 (CCR9) and its specific ligand CC motif chemokine ligand 25 (CCL25) are interesting candidate genes for celiac disease. These genes are located in regions previously shown to be associated with or linked to celiac disease, but no investigations on their association with various celiac disease phenotypes have so far been conducted. Here we studied such associations of both genotyped and imputed single nucleotide polymorphisms (SNPs) with either regulatory function or exonic location of the <i>CCR9</i> and <i>CCL25</i> loci.<h4>Results</h4>Exploiting a carefully phenotyped cohort of 625 celiac disease patients and 1817 non-celiac controls, we identified that multiple SNPs wi2021-01-01T00:00:00Z20212026-05-08T00:05:35.407Z2022-02-11T14:17:25.702ZS-EPMC86408693490181410.1016/j.jtauto.2021.100128