{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strunk C"],"funding":["NIMHD NIH HHS"],"pagination":["102612"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8643307"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["92"],"pubmed_abstract":["<h4>Background</h4>Sickle cell disease (SCD) is characterized by frequent, unpredictable pain episodes and other vaso-occlusive crises (VOCs) leading to significant healthcare utilization. VOC frequency is often an endpoint in clinical trials investigating novel therapies for this devastating disease.<h4>Procedure</h4>The Consortium for the Advancement of Sickle Cell Research (CASiRe) is an international collaboration investigating clinical severity in SCD using a validated questionnaire and medical chart review standardized across four countries (United States, United Kingdom, Italy and Ghana).<h4>Results</h4>This study, focused on pain crisis incidence and healthcare utilization, included 868 patients, equally represented according to age and gender. HgbSS was the most common genotype. P"],"journal":["Blood cells, molecules & diseases"],"pubmed_title":["Global geographic differences in healthcare utilization for sickle cell disease pain crises in the CASiRe cohort."],"pmcid":["PMC8643307"],"funding_grant_id":["T37 MD001425"],"pubmed_authors":["Rao S","Inusa B","Wilson S","Kim E","Ekem I","Rivers A","Farooq F","Boatemaa GD","Tartaglione I","Andemariam B","Colombatti R","Urbonya R","Haile H","Manwani D","Piccone CM","Boruchov D","Perrotta S","Segbefia C","Asare EV","Strunk C","Smith A","Antwi-Boasiako C","Campbell AD","Sey F","Zempsky W","Sainati L"],"additional_accession":[]},"is_claimable":false,"name":"Global geographic differences in healthcare utilization for sickle cell disease pain crises in the CASiRe cohort.","description":"<h4>Background</h4>Sickle cell disease (SCD) is characterized by frequent, unpredictable pain episodes and other vaso-occlusive crises (VOCs) leading to significant healthcare utilization. VOC frequency is often an endpoint in clinical trials investigating novel therapies for this devastating disease.<h4>Procedure</h4>The Consortium for the Advancement of Sickle Cell Research (CASiRe) is an international collaboration investigating clinical severity in SCD using a validated questionnaire and medical chart review standardized across four countries (United States, United Kingdom, Italy and Ghana).<h4>Results</h4>This study, focused on pain crisis incidence and healthcare utilization, included 868 patients, equally represented according to age and gender. HgbSS was the most common genotype. P","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-25T20:54:27.526Z","creation":"2025-04-06T08:32:57.304Z"},"accession":"S-EPMC8643307","cross_references":{"pubmed":["34564050"],"doi":["10.1016/j.bcmd.2021.102612"]}}