biostudies-literatureStrunk CNIMHD NIH HHS102612https://www.ebi.ac.uk/biostudies/studies/S-EPMC8643307biostudies-literatureUnknown92<h4>Background</h4>Sickle cell disease (SCD) is characterized by frequent, unpredictable pain episodes and other vaso-occlusive crises (VOCs) leading to significant healthcare utilization. VOC frequency is often an endpoint in clinical trials investigating novel therapies for this devastating disease.<h4>Procedure</h4>The Consortium for the Advancement of Sickle Cell Research (CASiRe) is an international collaboration investigating clinical severity in SCD using a validated questionnaire and medical chart review standardized across four countries (United States, United Kingdom, Italy and Ghana).<h4>Results</h4>This study, focused on pain crisis incidence and healthcare utilization, included 868 patients, equally represented according to age and gender. HgbSS was the most common genotype. PBlood cells, molecules & diseasesGlobal geographic differences in healthcare utilization for sickle cell disease pain crises in the CASiRe cohort.PMC8643307T37 MD001425Rao SInusa BWilson SKim EEkem IRivers AFarooq FBoatemaa GDTartaglione IAndemariam BColombatti RUrbonya RHaile HManwani DPiccone CMBoruchov DPerrotta SSegbefia CAsare EVStrunk CSmith AAntwi-Boasiako CCampbell ADSey FZempsky WSainati LfalseGlobal geographic differences in healthcare utilization for sickle cell disease pain crises in the CASiRe cohort.<h4>Background</h4>Sickle cell disease (SCD) is characterized by frequent, unpredictable pain episodes and other vaso-occlusive crises (VOCs) leading to significant healthcare utilization. VOC frequency is often an endpoint in clinical trials investigating novel therapies for this devastating disease.<h4>Procedure</h4>The Consortium for the Advancement of Sickle Cell Research (CASiRe) is an international collaboration investigating clinical severity in SCD using a validated questionnaire and medical chart review standardized across four countries (United States, United Kingdom, Italy and Ghana).<h4>Results</h4>This study, focused on pain crisis incidence and healthcare utilization, included 868 patients, equally represented according to age and gender. HgbSS was the most common genotype. P2021-01-01T00:00:00Z2021 Dec2025-04-25T20:54:27.526Z2025-04-06T08:32:57.304ZS-EPMC86433073456405010.1016/j.bcmd.2021.102612