{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kozminsky M"],"funding":["University of California, Berkeley","Fred Hutchinson Cancer Research Center","NIH/NCI","CITRIS COVID 19 Response Seed Funding","University of California Berkeley","NCI NIH HHS","Michael and Margaret Checca","University of California Cancer Research Coordinating Committee Fellowship"],"pagination":["e2101166"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8646752"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(23)"],"pubmed_abstract":["Lipid-based nanoparticles have been applied extensively in drug delivery and vaccine strategies and are finding diverse applications in the coronavirus disease 2019 (COVID-19) pandemic-from vaccine-component encapsulation to modeling the virus, itself. High-throughput, highly flexible methods for characterization are of great benefit to the development of liposomes featuring surface proteins. DNA-directed patterning is one such method that offers versatility in immobilizing and segregating lipid-based nanoparticles for subsequent analysis. Here, oligonucleotides are selectively conjugated onto a glass substrate and then hybridized to complementary oligonucleotides tagged to liposomes, patterning them with great control and precision. The power of DNA-directed patterning is demonstrated by "],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["DNA-Directed Patterning for Versatile Validation and Characterization of a Lipid-Based Nanoparticle Model of SARS-CoV-2."],"pmcid":["PMC8646752"],"funding_grant_id":["F32 CA243354","1F32CA243354-01"],"pubmed_authors":["Sohn LL","Carey TR","Kozminsky M"],"additional_accession":[]},"is_claimable":false,"name":"DNA-Directed Patterning for Versatile Validation and Characterization of a Lipid-Based Nanoparticle Model of SARS-CoV-2.","description":"Lipid-based nanoparticles have been applied extensively in drug delivery and vaccine strategies and are finding diverse applications in the coronavirus disease 2019 (COVID-19) pandemic-from vaccine-component encapsulation to modeling the virus, itself. High-throughput, highly flexible methods for characterization are of great benefit to the development of liposomes featuring surface proteins. DNA-directed patterning is one such method that offers versatility in immobilizing and segregating lipid-based nanoparticles for subsequent analysis. Here, oligonucleotides are selectively conjugated onto a glass substrate and then hybridized to complementary oligonucleotides tagged to liposomes, patterning them with great control and precision. The power of DNA-directed patterning is demonstrated by ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-08T00:05:41.157Z","creation":"2022-02-11T14:17:26.638Z"},"accession":"S-EPMC8646752","cross_references":{"pubmed":["34672117"],"doi":["10.1002/advs.202101166"]}}