biostudies-literatureModi ANIDCR NIH HHSNIMHD NIH HHSNational Institute of Dental and Craniofacial ResearchNational Institute on Minority Health and Health DisparitiesNIGMS NIH HHS3085-3094https://www.ebi.ac.uk/biostudies/studies/S-EPMC8650404biostudies-literatureUnknown31(11)<h4>Background and aims</h4>The recent COVID-19 pandemic has further increased the importance of reducing obesity and prediabetes/diabetes. We aimed to evaluate the association between adiposity and regression of prediabetes/diabetes.<h4>Methods and results</h4>The San Juan Overweight Adults Longitudinal Study (SOALS) included 1351 individuals with overweight/obesity, aged 40-65, free of major cardiovascular diseases and physician diagnosed diabetes. From the 1012 participants with baseline prediabetes/diabetes, 598 who completed the follow-up were included. Over the follow-up, 25% regressed from prediabetes to normoglycemia or from diabetes to prediabetes or normoglycemia. Poisson regression with robust standard error was used to estimate the relative risk (RR) adjusting for major confounNutrition, metabolism, and cardiovascular diseases : NMCDLongitudinal association between adiposity measures and regression of prediabetes/diabetes.PMC8650404R01 DE020111U54 GM133807U54 MD007587R01DE020111U54MD007587Joshipura KModi AGadhavi RPerez CMfalseLongitudinal association between adiposity measures and regression of prediabetes/diabetes.<h4>Background and aims</h4>The recent COVID-19 pandemic has further increased the importance of reducing obesity and prediabetes/diabetes. We aimed to evaluate the association between adiposity and regression of prediabetes/diabetes.<h4>Methods and results</h4>The San Juan Overweight Adults Longitudinal Study (SOALS) included 1351 individuals with overweight/obesity, aged 40-65, free of major cardiovascular diseases and physician diagnosed diabetes. From the 1012 participants with baseline prediabetes/diabetes, 598 who completed the follow-up were included. Over the follow-up, 25% regressed from prediabetes to normoglycemia or from diabetes to prediabetes or normoglycemia. Poisson regression with robust standard error was used to estimate the relative risk (RR) adjusting for major confoun2021-01-01T00:00:00Z2021 Oct2025-04-18T20:20:39.925Z2025-04-07T08:16:41.117ZS-EPMC86504043462925210.1016/j.numecd.2021.07.005