biostudies-literatureBooth SCancer Research UKUniversity of Birmingham, University of Oxford, Blood Cancer UKBlood Cancer UKNational Institute for Health Research (NIHR)892-901https://www.ebi.ac.uk/biostudies/studies/S-EPMC8652610biostudies-literatureUnknown196(4)Patients with haematological malignancies have a high risk of severe infection and death from SARS-CoV-2. In this prospective observational study, we investigated the impact of cancer type, disease activity, and treatment in 877 unvaccinated UK patients with SARS-CoV-2 infection and active haematological cancer. The primary end-point was all-cause mortality. In a multivariate analysis adjusted for age, sex and comorbidities, the highest mortality was in patients with acute leukaemia [odds ratio (OR) = 1·73, 95% confidence interval (CI) 1·1-2·72, P = 0·017] and myeloma (OR 1·3, 95% CI 0·96-1·76, P = 0·08). Having uncontrolled cancer (newly diagnosed awaiting treatment as well as relapsed or progressive disease) was associated with increased mortality risk (OR = 2·45, 95% CI 1·09-5·5, P = 0·British journal of haematologyKey findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID-19: disease control as an important factor relative to recent chemotherapy or anti-CD20 therapy.PMC86526103019520011CL-2018-18-002ACF-2017-19-002#20011Campton NAMoody SInnes AOram HSTillet TIllingworth JArnold RNewsom-Davies TUKCCMP teamCurley HMMiddleton GWrench DCollins GPApperly JCook LBDolly SRabin NCazier JBBooth SPettengell RGault ATilby MLee LYWPurshouse KAries JPalles CAltohami MCook GTomkins OKerr RMittal SMukherjee LVarnai CKulasekararaj AAshcroft JCarmichael JfalseKey findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID-19: disease control as an important factor relative to recent chemotherapy or anti-CD20 therapy.Patients with haematological malignancies have a high risk of severe infection and death from SARS-CoV-2. In this prospective observational study, we investigated the impact of cancer type, disease activity, and treatment in 877 unvaccinated UK patients with SARS-CoV-2 infection and active haematological cancer. The primary end-point was all-cause mortality. In a multivariate analysis adjusted for age, sex and comorbidities, the highest mortality was in patients with acute leukaemia [odds ratio (OR) = 1·73, 95% confidence interval (CI) 1·1-2·72, P = 0·017] and myeloma (OR 1·3, 95% CI 0·96-1·76, P = 0·08). Having uncontrolled cancer (newly diagnosed awaiting treatment as well as relapsed or progressive disease) was associated with increased mortality risk (OR = 2·45, 95% CI 1·09-5·5, P = 0·2022-01-01T00:00:00Z2022 Feb2025-04-04T22:43:32.376Z2022-02-11T13:43:18.403ZS-EPMC86526103476138910.1111/bjh.17937