{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Fundamental Research Funds for the Central Universities","National Key R&D Program of China","Fund of Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province","Open Research Project of Military Logistics Support Department","National Natural Science Foundation of China","Natural Science Foundation of Guangdong Province"],"pagination":["e2102561"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8655165"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(23)"],"pubmed_abstract":["Photodynamic therapy (PDT) has become a promising candidate for cancer theranostics; however, traditional photosensitizers (PSs) usually exhibit weak fluorescence and poor reactive oxygen species (ROS) generation efficiency when aggregated. Recently, aggregation-induced emission (AIE) luminogens have shown great potential in the development of novel PSs owing to their excellent aggregation-induced ROS generation (AIG-ROS) activity. However, there are still concerns that must be addressed. In this study, two near-infrared (NIR) emitters (PI and PTI) are synthesized with AIG-ROS characteristic. PTI exhibit a valuable redder emission with more effective intersystem crossing (ISC) process than PI. The two AIE-active PSs show excellent lipid droplet (LD)-specific targeting ability. The detailed"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Trojan Horse-Like Nano-AIE Aggregates Based on Homologous Targeting Strategy and Their Photodynamic Therapy in Anticancer Application."],"pmcid":["PMC8655165"],"funding_grant_id":["BLB19J008","2019ZD04","2020A1515011542","21975077","51603127","2017YFE0132200","2019B030301003","21788102"],"pubmed_authors":["Zhang W","Li Y","Wan Q","Hou J","Ma Y","Tang BZ","Zhang R","Hu R","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Trojan Horse-Like Nano-AIE Aggregates Based on Homologous Targeting Strategy and Their Photodynamic Therapy in Anticancer Application.","description":"Photodynamic therapy (PDT) has become a promising candidate for cancer theranostics; however, traditional photosensitizers (PSs) usually exhibit weak fluorescence and poor reactive oxygen species (ROS) generation efficiency when aggregated. Recently, aggregation-induced emission (AIE) luminogens have shown great potential in the development of novel PSs owing to their excellent aggregation-induced ROS generation (AIG-ROS) activity. However, there are still concerns that must be addressed. In this study, two near-infrared (NIR) emitters (PI and PTI) are synthesized with AIG-ROS characteristic. PTI exhibit a valuable redder emission with more effective intersystem crossing (ISC) process than PI. The two AIE-active PSs show excellent lipid droplet (LD)-specific targeting ability. The detailed","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-08T22:28:27.527Z","creation":"2022-02-11T13:49:53.197Z"},"accession":"S-EPMC8655165","cross_references":{"pubmed":["34672122"],"doi":["10.1002/advs.202102561"]}}