biostudies-literatureEom BWKorea Health Industry Development Institute (KHIDI), Ministry of Health &amp; Welfaree056187https://www.ebi.ac.uk/biostudies/studies/S-EPMC8655561biostudies-literatureUnknown11(12)<h4>Introduction</h4>Patients who underwent curative gastrectomy for gastric cancer are regularly followed-up for the early detection of recurrence and postoperative symptom management. However, there is a lack of evidence with regard to proper surveillance intervals and diagnostic tools. This study aims to evaluate whether frequent surveillance tests have a survival benefit or improve the quality of life in patients who underwent curative resection for advanced gastric cancer.<h4>Methods and analysis</h4>The STOFOLUP trial is an investigator-initiated, parallel-assigned, multicentre randomised controlled trial involving 16 hospitals in the Republic of Korea. Patients (n=886) diagnosed with pathological stage II or III gastric adenocarcinoma will be randomised to either the 3-month or the BMJ openProspective multicentre randomised clinical trial comparing survival rates, quality of life and nutritional status between advanced gastric cancer patients with different follow-up intensities: study protocol for the STOFOLUP trial.PMC8655561HI19C0481, HC20C0155Hur HRyu MHYoo CHKwon OKAn JYPark JHKim HIMin JSJeong OSeo KWRyu KWKoo DHBae JMLee HHRyu SWLee HJJeong SHEom BWKim SMYoo MWfalseProspective multicentre randomised clinical trial comparing survival rates, quality of life and nutritional status between advanced gastric cancer patients with different follow-up intensities: study protocol for the STOFOLUP trial.<h4>Introduction</h4>Patients who underwent curative gastrectomy for gastric cancer are regularly followed-up for the early detection of recurrence and postoperative symptom management. However, there is a lack of evidence with regard to proper surveillance intervals and diagnostic tools. This study aims to evaluate whether frequent surveillance tests have a survival benefit or improve the quality of life in patients who underwent curative resection for advanced gastric cancer.<h4>Methods and analysis</h4>The STOFOLUP trial is an investigator-initiated, parallel-assigned, multicentre randomised controlled trial involving 16 hospitals in the Republic of Korea. Patients (n=886) diagnosed with pathological stage II or III gastric adenocarcinoma will be randomised to either the 3-month or the 2021-01-01T00:00:00Z2021 Dec2026-05-31T05:04:29.715Z2025-02-19T01:54:43.456ZS-EPMC86555613488002810.1136/bmjopen-2021-056187