{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vivek S"],"funding":["NHLBI NIH HHS","University of Alabama at Birmingham","National Heart, Lung, and Blood Institute","Kaiser Foundation Research Institute","University of Minnesota","Northwestern University"],"pagination":["109004"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8655852"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["180"],"pubmed_abstract":["<h4>Aim</h4>To evaluate whether the extent of return to fasting state 2-hours after a glucose challenge among normoglycemic individuals is associated with lower risk of incident prediabetes/ type 2 diabetes in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort study.<h4>Methods</h4>We evaluated this association among 1879 normoglycemic adults who were categorized into three groups: 'Low post load' (2hPG < FPG); 'Medium post load' (2hPG ≥ FPG and < 75<sup>th</sup> percentile of the difference); and 'High post load' (2hPG > FPG and ≥ 75<sup>th</sup> percentile of the difference). We used Cox proportional hazards regression to evaluate the association of the difference in 2hPG and FPG with incident diabetes/prediabetes after adjustment for demographic and clinical covariates.<h4>Results</h4>During 20 years of follow-up, 8% developed type 2 diabetes and 35% developed prediabetes. Compared to those with 'Low post load', the risk of type 2 diabetes was higher for participants with 'High post load' [HR: 1.56, 95% CI (1.03, 2.37)] and similar for participants with 'Medium post load' [HR: 0.99, 95% CI (0.64, 1.52)]. However, HRs for incident prediabetes among participants with 'High post load' [HR = 1.2, 95 %CI = (0.98, 1.46)] was not significantly different compared to participants with 'Low post load'.<h4>Conclusion</h4>Among normoglycemic individuals, a difference between 2hPG and FPG concentration > 0.9 mmol/L can be used to stratify individuals at higher risk for developing type 2 diabetes."],"journal":["Diabetes research and clinical practice"],"pubmed_title":["Association of the extent of return to fasting state 2-hours after a glucose challenge with incident prediabetes and type 2 diabetes: The CARDIA study."],"pmcid":["PMC8655852"],"funding_grant_id":["HHSN268201800005I","HHSN268201800004I","HHSN268201800007I","HHSN268201800006I","HHSN268201800003I","N01HC48050","N01HC48049","N01HC48048","N01HC48047"],"pubmed_authors":["Prizment A","Thyagarajan B","Carnethon MR","Bancks MP","Carson AP","Jacobs DR","Vivek S"],"additional_accession":[]},"is_claimable":false,"name":"Association of the extent of return to fasting state 2-hours after a glucose challenge with incident prediabetes and type 2 diabetes: The CARDIA study.","description":"<h4>Aim</h4>To evaluate whether the extent of return to fasting state 2-hours after a glucose challenge among normoglycemic individuals is associated with lower risk of incident prediabetes/ type 2 diabetes in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort study.<h4>Methods</h4>We evaluated this association among 1879 normoglycemic adults who were categorized into three groups: 'Low post load' (2hPG < FPG); 'Medium post load' (2hPG ≥ FPG and < 75<sup>th</sup> percentile of the difference); and 'High post load' (2hPG > FPG and ≥ 75<sup>th</sup> percentile of the difference). We used Cox proportional hazards regression to evaluate the association of the difference in 2hPG and FPG with incident diabetes/prediabetes after adjustment for demographic and clinical covariates.<h4>Results</h4>During 20 years of follow-up, 8% developed type 2 diabetes and 35% developed prediabetes. Compared to those with 'Low post load', the risk of type 2 diabetes was higher for participants with 'High post load' [HR: 1.56, 95% CI (1.03, 2.37)] and similar for participants with 'Medium post load' [HR: 0.99, 95% CI (0.64, 1.52)]. However, HRs for incident prediabetes among participants with 'High post load' [HR = 1.2, 95 %CI = (0.98, 1.46)] was not significantly different compared to participants with 'Low post load'.<h4>Conclusion</h4>Among normoglycemic individuals, a difference between 2hPG and FPG concentration > 0.9 mmol/L can be used to stratify individuals at higher risk for developing type 2 diabetes.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-04T10:27:39.047Z","creation":"2025-04-04T10:27:39.047Z"},"accession":"S-EPMC8655852","cross_references":{"pubmed":["34391830"],"doi":["10.1016/j.diabres.2021.109004"]}}