biostudies-literatureVivek SNHLBI NIH HHSUniversity of Alabama at BirminghamNational Heart, Lung, and Blood InstituteKaiser Foundation Research InstituteUniversity of MinnesotaNorthwestern University109004https://www.ebi.ac.uk/biostudies/studies/S-EPMC8655852biostudies-literatureUnknown180<h4>Aim</h4>To evaluate whether the extent of return to fasting state 2-hours after a glucose challenge among normoglycemic individuals is associated with lower risk of incident prediabetes/ type 2 diabetes in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort study.<h4>Methods</h4>We evaluated this association among 1879 normoglycemic adults who were categorized into three groups: 'Low post load' (2hPG < FPG); 'Medium post load' (2hPG ≥ FPG and < 75^th percentile of the difference); and 'High post load' (2hPG > FPG and ≥ 75^th percentile of the difference). We used Cox proportional hazards regression to evaluate the association of the difference in 2hPG and FPG with incident diabetes/prediabetes after adjustment for demographic and clinical covariates.<h4>Results</h4>During 20 years of follow-up, 8% developed type 2 diabetes and 35% developed prediabetes. Compared to those with 'Low post load', the risk of type 2 diabetes was higher for participants with 'High post load' [HR: 1.56, 95% CI (1.03, 2.37)] and similar for participants with 'Medium post load' [HR: 0.99, 95% CI (0.64, 1.52)]. However, HRs for incident prediabetes among participants with 'High post load' [HR = 1.2, 95 %CI = (0.98, 1.46)] was not significantly different compared to participants with 'Low post load'.<h4>Conclusion</h4>Among normoglycemic individuals, a difference between 2hPG and FPG concentration > 0.9 mmol/L can be used to stratify individuals at higher risk for developing type 2 diabetes.Diabetes research and clinical practiceAssociation of the extent of return to fasting state 2-hours after a glucose challenge with incident prediabetes and type 2 diabetes: The CARDIA study.PMC8655852HHSN268201800005IHHSN268201800004IHHSN268201800007IHHSN268201800006IHHSN268201800003IN01HC48050N01HC48049N01HC48048N01HC48047Prizment AThyagarajan BCarnethon MRBancks MPCarson APJacobs DRVivek SfalseAssociation of the extent of return to fasting state 2-hours after a glucose challenge with incident prediabetes and type 2 diabetes: The CARDIA study.<h4>Aim</h4>To evaluate whether the extent of return to fasting state 2-hours after a glucose challenge among normoglycemic individuals is associated with lower risk of incident prediabetes/ type 2 diabetes in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort study.<h4>Methods</h4>We evaluated this association among 1879 normoglycemic adults who were categorized into three groups: 'Low post load' (2hPG < FPG); 'Medium post load' (2hPG ≥ FPG and < 75^th percentile of the difference); and 'High post load' (2hPG > FPG and ≥ 75^th percentile of the difference). We used Cox proportional hazards regression to evaluate the association of the difference in 2hPG and FPG with incident diabetes/prediabetes after adjustment for demographic and clinical covariates.<h4>Results</h4>During 20 years of follow-up, 8% developed type 2 diabetes and 35% developed prediabetes. Compared to those with 'Low post load', the risk of type 2 diabetes was higher for participants with 'High post load' [HR: 1.56, 95% CI (1.03, 2.37)] and similar for participants with 'Medium post load' [HR: 0.99, 95% CI (0.64, 1.52)]. However, HRs for incident prediabetes among participants with 'High post load' [HR = 1.2, 95 %CI = (0.98, 1.46)] was not significantly different compared to participants with 'Low post load'.<h4>Conclusion</h4>Among normoglycemic individuals, a difference between 2hPG and FPG concentration > 0.9 mmol/L can be used to stratify individuals at higher risk for developing type 2 diabetes.2021-01-01T00:00:00Z2021 Oct2025-04-04T10:27:39.047Z2025-04-04T10:27:39.047ZS-EPMC86558523439183010.1016/j.diabres.2021.109004