biostudies-literatureBlanchard PLigue Contre le CancerFrench Government Ministry of Higher Education and Research and InnovationInstitut National Du CancerNational Institute for Health Research (NIHR)59-68https://www.ebi.ac.uk/biostudies/studies/S-EPMC8660702biostudies-literatureUnknown32<h4>Purpose</h4>Chemotherapy, when added to radiotherapy, improves survival in locally advanced nasopharyngeal carcinoma (NPC). This article presents the second update of the Meta-Analysis of Chemotherapy in NPC.<h4>Methods</h4>Published or unpublished randomized trials assessing radiotherapy (±a second chemotherapy timing) with/without chemotherapy in non-metastatic NPC patients were identified. Updated data were sought for studies included in the previous rounds of the meta-analysis. The primary endpoint was overall survival. All trials were analyzed following the intent-to-treat principle using a fixed-effects model. Treatments were classified in five subsets according to chemotherapy timing. The statistical analysis plan was pre-specified.<h4>Results</h4>Eighteen new trials were identiClinical and translational radiation oncologyMeta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients.PMC8660702PHRC-K15-189NF-SI-0617-10145Pignon JPFountzilas GPun Hui ENgan RZhang LHiggins JLee Kiang Chua MLeBlanc MLTang LQPierre Pignon JChen YAuperin ALw Kwong DWu XOn Lam KCarmel APoh SSXBenhamou EChen LTung YBlanchard PHuang PYSun YOllivier CChakrabandhu SMai HQTan TXu TTt Chua DMoon JHsiao CFBourhis JLacas BSham JRucker GChoi HTc Chan ALai SCMo FO'Sullivan BHong RLChappell RJChan ATCWee JLim Soong YMAC-NPC collaborative GroupChen QYFun Victor Lee HChen MYWm Lee AKam MZhu GLi WFPetit CWai Tong NFei Li WLee AWMMa BHong MHTong Ng WPoh SXZhang YKwong DLWAngeliki Koliou GMa JfalseMeta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients.<h4>Purpose</h4>Chemotherapy, when added to radiotherapy, improves survival in locally advanced nasopharyngeal carcinoma (NPC). This article presents the second update of the Meta-Analysis of Chemotherapy in NPC.<h4>Methods</h4>Published or unpublished randomized trials assessing radiotherapy (±a second chemotherapy timing) with/without chemotherapy in non-metastatic NPC patients were identified. Updated data were sought for studies included in the previous rounds of the meta-analysis. The primary endpoint was overall survival. All trials were analyzed following the intent-to-treat principle using a fixed-effects model. Treatments were classified in five subsets according to chemotherapy timing. The statistical analysis plan was pre-specified.<h4>Results</h4>Eighteen new trials were identi2022-01-01T00:00:00Z2022 Jan2026-05-08T19:13:38.105Z2022-02-11T13:55:52.155ZS-EPMC86607023493577610.1016/j.ctro.2021.11.007