biostudies-literatureWang SLigue Contre le CancerInstitut Gustave-RoussyChinese Scholarship Council fellowshipsAssociation pour la Recherche sur le CancerChinese scholarship council fellowship. Fellowship from the french Scociety of HematologyInstitut National Du CancerFellowship from Association pour la Recherche sur le CancerNational Natural Science Foundation of ChinaCentre National de la Recherche ScientifiqueInstitut National de la Santé et de la Recherche Médicale1382https://www.ebi.ac.uk/biostudies/studies/S-EPMC8660792biostudies-literatureUnknown4(1)During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/"early EMP" and transient-definitive/"late EMP" waves both contribute to various resident primitive macrophage populations in the developing embryonic organs. Identifying factors that modulates early stages of macrophage progenitor development may lead to a better understanding of defective function of specific resident macrophage subsets. Here we show that YS primitive macrophage progenitors express Lyl-1, a bHLH transcription factor related to SCL/Tal-1. Transcriptomic analysis of YS macrophage progenitors indicate that primitive macrophage progenitors present at embryonic day 9 are clearly distinct Communications biologyLyl-1 regulates primitive macrophages and microglia development.PMC8660792certified teamPLBioTA DERE 17N°32000669Raslova HWang SPlo IRen DArkoun BKaushik ALMatherat GLecluse YFilipp DGodin IVainchenker WfalseLyl-1 regulates primitive macrophages and microglia development.During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/"early EMP" and transient-definitive/"late EMP" waves both contribute to various resident primitive macrophage populations in the developing embryonic organs. Identifying factors that modulates early stages of macrophage progenitor development may lead to a better understanding of defective function of specific resident macrophage subsets. Here we show that YS primitive macrophage progenitors express Lyl-1, a bHLH transcription factor related to SCL/Tal-1. Transcriptomic analysis of YS macrophage progenitors indicate that primitive macrophage progenitors present at embryonic day 9 are clearly distinct 2021-01-01T00:00:00Z2021 Dec2026-05-08T02:27:11.883Z2024-11-08T17:55:47.748ZS-EPMC86607923488750410.1038/s42003-021-02886-5