{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Beltran-Sanchez H"],"funding":["National Institute of Child Health and Development","NICHD NIH HHS","European Union Horizon 2020","European Research Council","Research and Innovation Programme","NIA NIH HHS","FIC NIH HHS","Fogarty International Center","National Institute on Aging","National Institute of Child Health and Human Development"],"pagination":["19-36"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8660937"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(1)"],"pubmed_abstract":["Evidence from theories of Developmental Origins of Health and Disease (DOHaD) suggests that experiencing adverse early life conditions subsequently leads to detrimental adult health outcomes. The bulk of empirical DOHaD literature does not consider the nature and magnitude of the impact of adverse early life conditions at the population level. In particular, it ignores the distortion of age and cohort patterns of adult health and mortality and the increased load of chronic illness and disability that ensues. In this paper, we use a microsimulation model combined with empirical estimates of incidence and prevalence of obesity, type 2 diabetes, and associated disability in low- and middle-income countries to assess the magnitude of delayed effects on adult healthy life expectancy and on comp"],"journal":["Population studies"],"pubmed_title":["Population-level impact of adverse early life conditions on adult healthy life expectancy in low- and middle-income countries."],"pmcid":["PMC8660937"],"funding_grant_id":["R37 AG025216","R01 AG018016","P2C HD041022","R01 AG052030","P30 AG017266","R24 HD041022","R01AG052030","R01 AG056608","R01 AG016209","D43 TW001586","P2C-HD041022","R24 HD047873"],"pubmed_authors":["Huangfu Y","McEniry M","Palloni A","Beltran-Sanchez H"],"additional_accession":[]},"is_claimable":false,"name":"Population-level impact of adverse early life conditions on adult healthy life expectancy in low- and middle-income countries.","description":"Evidence from theories of Developmental Origins of Health and Disease (DOHaD) suggests that experiencing adverse early life conditions subsequently leads to detrimental adult health outcomes. The bulk of empirical DOHaD literature does not consider the nature and magnitude of the impact of adverse early life conditions at the population level. In particular, it ignores the distortion of age and cohort patterns of adult health and mortality and the increased load of chronic illness and disability that ensues. In this paper, we use a microsimulation model combined with empirical estimates of incidence and prevalence of obesity, type 2 diabetes, and associated disability in low- and middle-income countries to assess the magnitude of delayed effects on adult healthy life expectancy and on comp","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T13:40:37.105Z","creation":"2025-04-04T13:40:37.105Z"},"accession":"S-EPMC8660937","cross_references":{"pubmed":["34110269"],"doi":["10.1080/00324728.2021.1933149"]}}