biostudies-literatureSell LBNINDS NIH HHSNational Institutes of Health108766https://www.ebi.ac.uk/biostudies/studies/S-EPMC8660955biostudies-literatureUnknown235Farnesol is a 15‑carbon organic isoprenol synthesized by plants and mammals with anti-oxidant, anti-inflammatory, and neuroprotective activities. We sought to determine whether farnesol treatment would result in protection against murine experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis (MS). We compared disease progression and severity in C57BL/6 mice treated orally with 100 mg/kg/day farnesol solubilized in corn oil to corn-oil treated and untreated EAE mice. Farnesol significantly delayed the onset of EAE (by ~2 days) and dramatically decreased disease severity (~80%) compared to controls. Disease protection by farnesol was associated with a significant reduction in spinal cord infiltration by monocytes-macrophages, dendritic cells, CD4<sup>Clinical immunology (Orlando, Fla.)Farnesol induces protection against murine CNS inflammatory demyelination and modifies gut microbiome.PMC8660955R15 NS107743Doyle WJRamelow CCGibson KMKohl HMSell LBStrawn KDHoffman KOchoa-Reparaz JBains JKKirby TORoullet JBHevrin TfalseFarnesol induces protection against murine CNS inflammatory demyelination and modifies gut microbiome.Farnesol is a 15‑carbon organic isoprenol synthesized by plants and mammals with anti-oxidant, anti-inflammatory, and neuroprotective activities. We sought to determine whether farnesol treatment would result in protection against murine experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis (MS). We compared disease progression and severity in C57BL/6 mice treated orally with 100 mg/kg/day farnesol solubilized in corn oil to corn-oil treated and untreated EAE mice. Farnesol significantly delayed the onset of EAE (by ~2 days) and dramatically decreased disease severity (~80%) compared to controls. Disease protection by farnesol was associated with a significant reduction in spinal cord infiltration by monocytes-macrophages, dendritic cells, CD4<sup>2022-01-01T00:00:00Z2022 Feb2025-04-19T17:57:52.273Z2025-04-19T17:57:52.273ZS-EPMC86609553409101810.1016/j.clim.2021.108766