biostudies-literatureUnknown4(12)Thome C<h4>Importance</h4>Patients with large annular defects following lumbar microdiscectomy for disc herniation are at increased risk for symptomatic recurrence and reoperation.<h4>Objective</h4>To determine whether a bone-anchored annular closure device in addition to lumbar microdiscectomy resulted in lower reherniation and reoperation rates vs lumbar microdiscectomy alone.<h4>Design, setting, and participants</h4>This secondary analysis of a multicenter randomized clinical trial reports 5-year follow-up for enrolled patients between December 2010 and October 2014 at 21 clinical sites. Patients in this study had a large annular defect (6-10 mm width) following lumbar microdiscectomy for treatment of lumbar disc herniation. Statistical analysis was performed from November to December 2020.<h4JAMA network opene2136809https://www.ebi.ac.uk/biostudies/studies/S-EPMC8662371biostudies-literatureEffectiveness of an Annular Closure Device to Prevent Recurrent Lumbar Disc Herniation: A Secondary Analysis With 5 Years of Follow-up.PMC8662371Bostelmann RThome CFluh CAssaker RVajkoczy PBarth MAnnular Closure RCT Study GroupKursumovic AKlassen PDEustacchio SHes RMiller LEBouma GJVan de Kelft ENanda DKohler HPFandino JMartens FArts MBrenke CKienzler JCfalseEffectiveness of an Annular Closure Device to Prevent Recurrent Lumbar Disc Herniation: A Secondary Analysis With 5 Years of Follow-up.<h4>Importance</h4>Patients with large annular defects following lumbar microdiscectomy for disc herniation are at increased risk for symptomatic recurrence and reoperation.<h4>Objective</h4>To determine whether a bone-anchored annular closure device in addition to lumbar microdiscectomy resulted in lower reherniation and reoperation rates vs lumbar microdiscectomy alone.<h4>Design, setting, and participants</h4>This secondary analysis of a multicenter randomized clinical trial reports 5-year follow-up for enrolled patients between December 2010 and October 2014 at 21 clinical sites. Patients in this study had a large annular defect (6-10 mm width) following lumbar microdiscectomy for treatment of lumbar disc herniation. Statistical analysis was performed from November to December 2020.<h42021-01-01T00:00:00Z2021 Dec2026-05-31T05:04:21.007Z2025-02-19T01:55:09.298ZS-EPMC86623713488218310.1001/jamanetworkopen.2021.36809