{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Pal L"],"pubmed_abstract":["TB-IRIS is an abnormal inflammatory response in a subset of HIV-TB co-infected patients shortly after initiation of anti-retroviral therapy (ART). Therapy in these patients could have greatly improved the life expectancy as ART reconstitutes the function and number of CD4+ T cells and many patients see improvement in symptoms but paradoxically up to 54% of co-infected patients develop TB-IRIS. Different studies have indicated that both innate and adaptive immunity are involved in the pathology of IRIS but the role of macrophages in abnormal activation of CD4+ T cells is poorly understood. Since macrophages are one of the major antigen-presenting cells and are infected by M.tb at a high frequency, they are very much likely to be involved in the development of TB-IRIS. In this study, we have"],"journal":["Frontiers in immunology"],"pagination":["775177"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8662811"],"repository":["biostudies-literature"],"pubmed_title":["Macrophages Are the Key Players in Promoting Hyper-Inflammatory Response in a Mouse Model of TB-IRIS."],"pmcid":["PMC8662811"],"pubmed_authors":["Pal L","Swami B","Roy G","Kumar P","Nandani R","Bhaskar S"],"additional_accession":[]},"is_claimable":false,"name":"Macrophages Are the Key Players in Promoting Hyper-Inflammatory Response in a Mouse Model of TB-IRIS.","description":"TB-IRIS is an abnormal inflammatory response in a subset of HIV-TB co-infected patients shortly after initiation of anti-retroviral therapy (ART). Therapy in these patients could have greatly improved the life expectancy as ART reconstitutes the function and number of CD4+ T cells and many patients see improvement in symptoms but paradoxically up to 54% of co-infected patients develop TB-IRIS. Different studies have indicated that both innate and adaptive immunity are involved in the pathology of IRIS but the role of macrophages in abnormal activation of CD4+ T cells is poorly understood. Since macrophages are one of the major antigen-presenting cells and are infected by M.tb at a high frequency, they are very much likely to be involved in the development of TB-IRIS. In this study, we have","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-05-31T23:31:29.728Z","creation":"2025-05-31T23:31:29.728Z"},"accession":"S-EPMC8662811","cross_references":{"pubmed":["34899731"],"doi":["10.3389/fimmu.2021.775177"]}}