biostudies-literatureRangan GKNational Health and Medical Research CouncilPKD Australiae046539https://www.ebi.ac.uk/biostudies/studies/S-EPMC8663108biostudies-literatureUnknown11(12)<h4>Introduction</h4>Excessive water intake is rarely associated with life-threatening hyponatraemia. The aim of this study was to determine the clinical characteristics and outcomes of hyponatraemia associated with excess water intake.<h4>Methods</h4>This review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All studies (case reports, observational or interventional studies) reporting excess water intake and hyponatraemia in adults (1946-2019) were included.<h4>Results</h4>A total of 2970 articles were identified and 177 were included (88.7% case reports), consisting of 590 patients. The mean age was 46±16 years (95% CI 44 to 48 years), 47% female, 52% had a chronic psychiatric disorder and 31% had no underlying condition. The mBMJ openClinical characteristics and outcomes of hyponatraemia associated with oral water intake in adults: a systematic review.PMC8663108N/A11385331164128Chandra ANZhang MMDorani NMunt AAbu-Zarour LLau HCWong ATRangan GKHowell MZhang JQJRangan ASaravanabavan SfalseClinical characteristics and outcomes of hyponatraemia associated with oral water intake in adults: a systematic review.<h4>Introduction</h4>Excessive water intake is rarely associated with life-threatening hyponatraemia. The aim of this study was to determine the clinical characteristics and outcomes of hyponatraemia associated with excess water intake.<h4>Methods</h4>This review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All studies (case reports, observational or interventional studies) reporting excess water intake and hyponatraemia in adults (1946-2019) were included.<h4>Results</h4>A total of 2970 articles were identified and 177 were included (88.7% case reports), consisting of 590 patients. The mean age was 46±16 years (95% CI 44 to 48 years), 47% female, 52% had a chronic psychiatric disorder and 31% had no underlying condition. The m2021-01-01T00:00:00Z2021 Dec2025-04-19T16:20:38.28Z2024-12-03T16:40:31.19ZS-EPMC86631083488726710.1136/bmjopen-2020-046539