{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shiau S"],"funding":["NIA NIH HHS","NIMH NIH HHS","National Institute of Mental Health","National Institute on Aging"],"pagination":["1982-1991"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8664485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(11)"],"pubmed_abstract":["Background
Accelerated epigenetic aging using DNA methylation (DNAm)-based biomarkers has been reported in people with human immunodeficiency virus (HIV, PWH), but limited data are available among African Americans (AA), women, and older PWH.Methods
DNAm was measured using Illumina EPIC Arrays for 107 (69 PWH and 38 HIV-seronegative controls) AA adults ≥60 years in New York City. Six DNAm-based biomarkers of aging were estimated: (1) epigenetic age acceleration (EAA), (2) extrinsic epigenetic age acceleration (EEAA), (3) intrinsic epigenetic age acceleration (IEAA), (4) GrimAge, (5) PhenoAge, and (6) DNAm-estimated telomere length (DNAm-TL). The National Institutes of Health (NIH) Toolbox Cognition Battery (domains: executive function, attention, working memory, processing "],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["Epigenetic Aging Biomarkers Associated With Cognitive Impairment in Older African American Adults With Human Immunodeficiency Virus (HIV)."],"pmcid":["PMC8664485"],"funding_grant_id":["R21 AG056175","R25 MH108389"],"pubmed_authors":["Yin MT","Arpadi SM","Jang G","Brickman AM","Shiau S","Baccarelli AA","Shen Y","Manly JJ","Ramon CV","Cantos A","Shah J"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic Aging Biomarkers Associated With Cognitive Impairment in Older African American Adults With Human Immunodeficiency Virus (HIV).","description":"Background
Accelerated epigenetic aging using DNA methylation (DNAm)-based biomarkers has been reported in people with human immunodeficiency virus (HIV, PWH), but limited data are available among African Americans (AA), women, and older PWH.Methods
DNAm was measured using Illumina EPIC Arrays for 107 (69 PWH and 38 HIV-seronegative controls) AA adults ≥60 years in New York City. Six DNAm-based biomarkers of aging were estimated: (1) epigenetic age acceleration (EAA), (2) extrinsic epigenetic age acceleration (EEAA), (3) intrinsic epigenetic age acceleration (IEAA), (4) GrimAge, (5) PhenoAge, and (6) DNAm-estimated telomere length (DNAm-TL). The National Institutes of Health (NIH) Toolbox Cognition Battery (domains: executive function, attention, working memory, processing ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-22T06:49:42.78Z","creation":"2025-04-05T21:54:56.606Z"},"accession":"S-EPMC8664485","cross_references":{"pubmed":["34143869"],"doi":["10.1093/cid/ciab563"]}}