biostudies-literatureShiau SNIA NIH HHSNIMH NIH HHSNational Institute of Mental HealthNational Institute on Aging1982-1991https://www.ebi.ac.uk/biostudies/studies/S-EPMC8664485biostudies-literatureUnknown73(11)<h4>Background</h4>Accelerated epigenetic aging using DNA methylation (DNAm)-based biomarkers has been reported in people with human immunodeficiency virus (HIV, PWH), but limited data are available among African Americans (AA), women, and older PWH.<h4>Methods</h4>DNAm was measured using Illumina EPIC Arrays for 107 (69 PWH and 38 HIV-seronegative controls) AA adults ≥60 years in New York City. Six DNAm-based biomarkers of aging were estimated: (1) epigenetic age acceleration (EAA), (2) extrinsic epigenetic age acceleration (EEAA), (3) intrinsic epigenetic age acceleration (IEAA), (4) GrimAge, (5) PhenoAge, and (6) DNAm-estimated telomere length (DNAm-TL). The National Institutes of Health (NIH) Toolbox Cognition Battery (domains: executive function, attention, working memory, processing Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaEpigenetic Aging Biomarkers Associated With Cognitive Impairment in Older African American Adults With Human Immunodeficiency Virus (HIV).PMC8664485R21 AG056175R25 MH108389Yin MTArpadi SMJang GBrickman AMShiau SBaccarelli AAShen YManly JJRamon CVCantos AShah JfalseEpigenetic Aging Biomarkers Associated With Cognitive Impairment in Older African American Adults With Human Immunodeficiency Virus (HIV).<h4>Background</h4>Accelerated epigenetic aging using DNA methylation (DNAm)-based biomarkers has been reported in people with human immunodeficiency virus (HIV, PWH), but limited data are available among African Americans (AA), women, and older PWH.<h4>Methods</h4>DNAm was measured using Illumina EPIC Arrays for 107 (69 PWH and 38 HIV-seronegative controls) AA adults ≥60 years in New York City. Six DNAm-based biomarkers of aging were estimated: (1) epigenetic age acceleration (EAA), (2) extrinsic epigenetic age acceleration (EEAA), (3) intrinsic epigenetic age acceleration (IEAA), (4) GrimAge, (5) PhenoAge, and (6) DNAm-estimated telomere length (DNAm-TL). The National Institutes of Health (NIH) Toolbox Cognition Battery (domains: executive function, attention, working memory, processing 2021-01-01T00:00:00Z2021 Dec2025-04-22T06:49:42.78Z2025-04-05T21:54:56.606ZS-EPMC86644853414386910.1093/cid/ciab563