biostudies-literatureSrinivasa SNational Center for Advancing Translational SciencesNational Center for Research ResourcesNational Institutes of HealthHarvard Catalystbvab175https://www.ebi.ac.uk/biostudies/studies/S-EPMC8664688biostudies-literatureUnknown6(1)Subclinical myocardial dysfunction is prevalent among well-treated persons with HIV (PWH). We have previously demonstrated unique renin-angiotensin-aldosterone system physiology among PWH with metabolic dysregulation. Mineralocorticoid receptor blockade may be a targeted treatment strategy for subclinical heart disease in PWH. Forty-six PWH were randomized to receive either eplerenone 50 mg daily or placebo in a 6-month randomized, double-blinded, placebo-controlled trial. We assessed changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP), a biomarker of cardiac stretch, under controlled posture and dietary conditions. The eplerenone- and placebo-treated groups demonstrated a long duration of HIV with good immunological control. NT-proBNP levels were similar between the groups atJournal of the Endocrine SocietyEvaluation of Mineralocorticoid Receptor Antagonism on Changes in NT-proBNP Among Persons With HIV.PMC8664688R01 HL15129R01 DK49302UL1 RR025758UL1 TR001102P30 DK040561K24 HL103845K23 HL136262UL1 TR000170Fitch KVSrinivasa SAdler GKThomas TSdeFilippi CIyengar SBurdo THWalpert ARGrinspoon SKShen GfalseEvaluation of Mineralocorticoid Receptor Antagonism on Changes in NT-proBNP Among Persons With HIV.Subclinical myocardial dysfunction is prevalent among well-treated persons with HIV (PWH). We have previously demonstrated unique renin-angiotensin-aldosterone system physiology among PWH with metabolic dysregulation. Mineralocorticoid receptor blockade may be a targeted treatment strategy for subclinical heart disease in PWH. Forty-six PWH were randomized to receive either eplerenone 50 mg daily or placebo in a 6-month randomized, double-blinded, placebo-controlled trial. We assessed changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP), a biomarker of cardiac stretch, under controlled posture and dietary conditions. The eplerenone- and placebo-treated groups demonstrated a long duration of HIV with good immunological control. NT-proBNP levels were similar between the groups at2022-01-01T00:00:00Z2022 Jan2025-04-26T03:57:51.304Z2022-02-11T14:05:27.349ZS-EPMC86646883490951810.1210/jendso/bvab175