{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Ben-Haim MS"],"funding":["Herczeg Institute of Aging","Flight Attendant Medical Research Institute","Esther B. Kahn Charitable Foundation","The Ernest and Bonnie Beutler Research Program."],"pubmed_abstract":["The prevalent m<sup>6</sup>Am mRNA cap modification was recently identified as a valid target for removal by the human obesity gene FTO along with the previously established m<sup>6</sup>A mRNA modification. However, the deposition and dynamics of m<sup>6</sup>Am in regulating obesity are unknown. Here, we investigate the liver m<sup>6</sup>A/m methylomes in mice fed on a high fat Western-diet and in ob/ob mice. We find that FTO levels are elevated in fat mice, and that genes which lost m<sup>6</sup>Am marking under obesity are overly downregulated, including the two fatty-acid-binding proteins FABP2, and FABP5. Furthermore, the cellular perturbation of FTO correspondingly affect protein levels of its targets. Notably, generally m<sup>6</sup>Am- but not m<sup>6</sup>A-methylated genes, are"],"journal":["Nature communications"],"pagination":["7185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8664860"],"repository":["biostudies-literature"],"pubmed_title":["Dynamic regulation of N<sup>6</sup>,2'-O-dimethyladenosine (m<sup>6</sup>Am) in obesity."],"pmcid":["PMC8664860"],"pubmed_authors":["Cohen HY","Kol N","Rechavi G","Hershkovitz V","Moshitch-Moshkovitz S","Pinto Y","Amariglio N","Ben-Haim MS","Diamant-Levi T","Beeri MS"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic regulation of N<sup>6</sup>,2'-O-dimethyladenosine (m<sup>6</sup>Am) in obesity.","description":"The prevalent m<sup>6</sup>Am mRNA cap modification was recently identified as a valid target for removal by the human obesity gene FTO along with the previously established m<sup>6</sup>A mRNA modification. However, the deposition and dynamics of m<sup>6</sup>Am in regulating obesity are unknown. Here, we investigate the liver m<sup>6</sup>A/m methylomes in mice fed on a high fat Western-diet and in ob/ob mice. We find that FTO levels are elevated in fat mice, and that genes which lost m<sup>6</sup>Am marking under obesity are overly downregulated, including the two fatty-acid-binding proteins FABP2, and FABP5. Furthermore, the cellular perturbation of FTO correspondingly affect protein levels of its targets. Notably, generally m<sup>6</sup>Am- but not m<sup>6</sup>A-methylated genes, are","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-09T15:13:13.119Z","creation":"2024-11-07T13:37:25.609Z"},"accession":"S-EPMC8664860","cross_references":{"pubmed":["34893620"],"doi":["10.1038/s41467-021-27421-2"]}}